“What are the effects of ketamine on updating negative beliefs in patients with treatment-resistant depression?” This is the question posed by researchers from Inserm, CNRS, Sorbonne University and doctors from AP-HP at the Institut du Cerveau. “Depressed patients gradually develop negative beliefs regarding themselves, the world and the future, sometimes evolving into suicidal ideas. These negative beliefs remain even when the patient receives positive information” underline the Inserm researchers.
About one-third of people with depression fail to respond to the most commonly prescribed antidepressants, leading to a diagnosis of treatment-resistant depression (TRD). For these patients, the search for new effective treatments is a priority, and ketamine is one of the molecules on which scientists currently hold the most hope. This anesthetic commonly used in veterinary medicine has indeed shown an effect on resistant depression.
A quick effect on depression
“While conventional antidepressant treatments take time to act (on average three weeks), ketamine produces a rapid antidepressant effect, only a few hours following its administration. But the mechanisms associated with this rapid-acting antidepressant effect are still misunderstood” underline the (…)
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