2023-09-01 05:42:46
Prof. Dr. Teerawat Hemachutha, Professor of Prasatology Faculty of Medicine Chulalongkorn University has issued a warning cathartic laxative Don’t use it too often. Risk of dementia.
People who use a type of laxative called osmotic laxatives on a regular basis, there is a riskdementiaincreased compared to those who did not use up to 64%
And people who used one or more types of laxatives, including bulk-forming, stool softening, and stimulant laxatives, had a 90% higher risk.
There are several types of laxatives, including:
A type of laxative that draws water into the intestines and softens loose stools. And easier to pass (oxidative laxatives), such as lactulose polyethylene glycol sorbitol magnesium citrate sodium acid phosphate
kind of laxative It acts by increasing the amount of stool.
(bulk forming laxatives), eg mucillin metamucil
Stool softening (emollient) laxatives, such as colace docusate sodium arachis oil, help water and fluid mix with the stool.
Stimulant laxatives such as bisacodyl, dulcolax senna, and senokot sodium picosulfate stimulate the nerves that control the muscles to increase intestinal peristalsis.
The nature of constipation at various levels is a phenomenon. that are found frequently and are increasing steadily when getting older It is also possible to use different types of laxatives to alter the microflora or bacteria in the gut. through a mechanism that is transmitted from the nerves of the intestine up to the brain and by enhancing the production of toxins that cause inflammation leaky intestinal walland spread throughout the body and affect the functioning of the brain
The population included in this reporting cohort was 502,229, of which 54% were women, and all had a mean age of 57 at study start. All of them had no symptoms of dementia in the beginning.
Of the 18,335 people included in the study, 3.6% were using over-the-counter (OTC) laxatives, using them regularly for several days of the week. during the month prior to the start of the study
The average total follow-up was 9.8 years with 218 cases, or 1.3% of those taking laxatives consistently, having dementia, while 1,969 cases, or 0.4% of their counterparts, not taking laxatives at all. dementia
when making adjustments or factors including age education level sex illness and other drugs used, including Is there a family history of dementia?
It was found that regular use of laxatives Significantly increased risk of all-cause dementia (adjusted hazard ratio) [aHR]1.51; 95% CI 1.30–1.75) and the risk of generalized capillary dementia or vascular dementia (aHR, 1.65; 95% CI, 1.21–2.27). Alzheimer’s dementia
(aHR, 1.05; 95% CI, 0.79–1.40)
Dementia risk also depends on the type or type of laxative.
For those who use oxidative laxatives alone, there is a risk of all types of dementia. with statistical significance (aHR, 1.64; 95% CI, 1.20–2.24) and risk of vascular dementia (aHR, 1.97; 95% CI 1.04–3.75).
However, it was not possible to determine whether the dose of laxatives used in the population included in this study had an effect on dementia.
such information It’s shocking information. and support interrelated links between gut health and microbial health and defined good and bad bacteria The immune system continues to the nerves and hits the brain.
but at the same time still unable to conclude or prove rationally of the use of laxatives in the incidence of dementia mentioned above, but further in-depth study is required. both at the animal and human levels.
It is worth noting that different types and types of this laxative are used. Instead, they did not find an increased risk of Alzheimer’s dementia, which may be a limitation of the data or a limitation of dementia type identification, or may be in fact unrelated.
In summary regarding constipation or “hard elements” that the ancient people said by reiterating to his children that If not taken, there will be accumulated toxins all over the body, probably true.
And the easiest way is to eat a lot of vegetables, fruits, fiber on a regular basis, several meals a day. The fibrous fruits and vegetables act as wonderful laxatives. But there is a condition that you must drink a lot of water to be effective. And, of course, it has to be as chemical free as possible.
havingconstipationThis has been noticed since many 100 years ago when Dr. James Parkinson have noticed that patients who later develop Parkinson’s disease have constipation brought before and in people who were born with the disease When constipation improves, the disease or Parkinson’s disease also improves.
All emphasize Taking care of your body, food, eating, and exercising, which, if possible, will result in good results from head to toe.
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Thank you for information from Thiravat Hemachudha
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