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(Seoul = Yonhap News) Reporter Seonggan Han = Vitamin D deficiency is directly related to the risk of dementia, a study has found.
This was the result of a Mendelian randomization analysis of 294,514 UK Biobank genetic data by a research team led by Professor Elina Hipponen, director of the Center for Precision Health at the University of South Australia. The Australian daily, The Australian, reported on the internet version of this on the 15th.
Mendelian random analysis is a research method that infers a causal relationship by analyzing the association between environmental risk factors for a specific disease and genetic mutations related to it.
People with a vitamin D blood level of 25 nmol/L had a 54% higher risk of dementia than those with 50 nmol/L, the researchers found.
It was analyzed that 17% of dementia patients might be prevented by raising the vitamin D blood level from 25 nmol/L to 50 nmol/L.
Blood levels of vitamin D should be at least 50 nmol/L, but 31% of Australian adults fall below it, the researchers said.
It was analyzed that a genetic causal relationship was established between vitamin D deficiency and dementia.
People deficient in vitamin D have smaller brains and a higher risk of dementia and stroke.
It is biologically possible that vitamin D protects brain health, the team explains.
First, there is a vitamin D receptor in the hippocampus, the memory center of the brain. This may suggest that vitamin D promotes the growth and maturation of neurons through the function of neurosteroids.
Second, vitamin D may be associated with the reduction of blood clots and the regulation of the renin-angiotensin system.
Third, vitamin D is presumed to protect the brain by inhibiting excessive inflammatory neurovascular damage caused by the decline of cytokines and amyloid proteins, which are commonly observed in Alzheimer’s dementia.
The results of this study were published in the American Journal of Clinical Nutrition.
skhan@yna.co.kr
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