2023-05-03 07:49:19
[Ming Pao News]There are two types of anti-cancer targeted drugs, including monoclonal antibodies (monoclonal antibodies), and other oral targeted drugs. Monoclonal antibody is referred to as “monoclonal antibody” for short. It belongs to immunotherapy and generally requires intravenous drip injection. Some monoclonal antibodies have subcutaneous injection formulations.
The new generation of monoclonal antibody modified antibody protein has better curative effect
Monoclonal antibodies target the antigenic protein on the surface of cancer cells and accurately kill cancer cells, so they are also called magic bullets. The new generation of monoclonal antibody uses new technology to modify the antibody protein, and the curative effect is better. Changing the animal monoclonal antibody protein into human monoclonal antibody protein can prevent the patient’s immune system from rejecting the imported animal monoclonal antibody. Fragmentation of the monoclonal antibody protein can make the small antibody produced more invasive and enhance the curative effect. There is also a new technology that combines two kinds of monoclonal antibodies targeting different antigenic proteins into a dual-target monoclonal antibody, so that anti-cancer T cells can bind to cancer cells and cause cancer cells to die. Adding toxins, drugs or radiation to the monoclonal antibody protein can also greatly enhance the curative effect.
Related reading:[blood cancer]the number of elderly cancer patients is increasing, and the side effects are controllable with targeted drugs and gentle treatment (the doctor’s words are reasonable)
Case: Lymph node swelling monoclonal antibody combined with chemotherapy
60-year-old Mr. Chen had swollen lymph nodes all over his body, and a biopsy confirmed the diagnosis of diffuse large B cell lymphoma (diffuse large B cell lymphoma). The treatment plan was anti-CD20 monoclonal antibody rituximab plus chemotherapy, with a high chance of cure.
The 65-year-old Mrs. Lam also had swollen lymph nodes all over her body, and a biopsy confirmed follicular B cell lymphoma (follicular B cell lymphoma); there were cancer cells in the bone marrow, which belonged to stage IV. The treatment plan is the new generation anti-CD20 monoclonal antibody atezolizumab (obinutuzumab) plus chemotherapy, and the curative effect is good.
20-year-old Ms. Li had a large tumor in the thoracic mediastinum, and was diagnosed with Hodgkin’s lymphoma by biopsy; the treatment plan used the CD30 monoclonal antibody brentuximab containing toxin vedotin plus Chemotherapy has a high chance of cure.
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Related reading: 【Lymphoma】Divided into four stages, there are multiple methods of treatment. Pay attention to the 3 major warning signs of lymphoma. Early diagnosis has a high cure rate.
Text: Liang Xiansun (specialist in hematology and hematology oncology)
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