2023-09-11 08:51:40
“Cell dust” or “extracellular vesicles” (Extracellular Vesicles) are born from every type of cell in the body. They are commonly found in tissues and body fluids. They range in size from 30 nanometers to 4,000 nanometers.
Cell dust plays an important role in communication between neighboring cells. or cells that are far away The cell dust carries various biomolecules. Whether it is proteins, nucleic acids, lipids, including antigens and integrins (Integrin) on the surface of cell dust that represents the source cell of the cell dust.
When the dust cells interact with the receptor cells Will cause various reactions. of the receiver cell It depends on what type of recipient cell it is. An obvious example is the communication between different types of nerve cells. that control blood vessels (Neurovascular Unit) such as neurons, microglia, glial cells or astrocytes (Astrocytes) and endothelial cells. In normal conditions, various cells work well together.
But in abnormal conditions, such as in stroke, dementia, Alzheimer’s Disease, and Parkinson’s Disease, various cells will not work together, causing brain disease to occur.
Researchers believe that one factor is the influence of cell dust. Therefore, there is a lot of research related to the analysis of biomolecules in cell dust to be biological indicators (Biomarkers) of disease occurrence in the group of NCDs or chronic non-communicable diseases. Such as diseases of the nervous system, heart and blood vessels, which are diseases with a high incidence in the world including Thailand.
With engineering technology to modify “cell dust” or “exosomes” (Exosome), work by medical researchers. And the research team developed a method to use biomolecules within cell dust, such as microRNA, as “indexes for disease activity” and drug delivery. or biomolecules for “Treatment on the spot” in diseases of the nervous system, heart and blood vessels, which is an important step in expanding towards production for real treatment for patients on a large scale under GMP (Good Manufacturing Practices) standards for the first time in Thailand.
Professor Emeritus Dr. Kowit Phatthana Panyasat Head of the Special Equipment for Research Unit Research Promotion Center Faculty of Medicine Siriraj Hospital As a teacher and researcher from Mahidol University Recipients of grants to promote high potential research groups for the year 2022 – 2023 organized by the National Research Council of Thailand (NRCT) and the National Science and Technology Development Agency (NSTDA), Ministry of Higher Education and Science. Research and innovation
Leading the research team from Mahidol University, Naresuan University and Chiang Mai University For targeted treatment in diseases of the nervous system, heart, and blood vessels by applying the method of coating cell dust surfaces with guiding molecules or adding good biomolecules. which is like “Medicine” goes into the production area inside the cell dust. Continuing on from the world’s leading researchers who have already invented and developed this method to successfully treat cancer patients directly.
When NCDs patients receive a blood draw Cell dust is often found in the blood in higher amounts than normal people. Due to the properties of cell dust, which can communicate with other cells, it carries things from the “mother cell” that are rich in protein. and biomolecules which can be both beneficial and harmful. If it’s a good type of protein, it will “give you”
But if it is an infected cell, it will be “harmful” and will cause disease in the body. Therefore, research is needed to find some biomolecules that can be used as “Disease indicators” or engineering and modifying the packaging of certain biomolecules that “give you” the hope of becoming medicine to treat disease further.
In addition, Professor Emeritus Dr. Kowit Develop wisdom Also explains further: “Dust Cell Modification Engineering Technology” is still more advanced. “Stem cell transplant technology” requires compatibility between “donor” cells and “recipient” cells, and can only be treated on an individual basis.
Meanwhile, “Dust Cell Engineering Technology” can produce large quantities of engineered dust cells to treat a larger number of patients. This is considered the ultimate goal of the research project. to get together with Department of Medical Sciences, Ministry of Public Health To raise the production level to GMP standards in the future.
In addition, safety can be assured that it will not result in side effects because “cell dust” is what is produced. and comes out of the “mother cell” without any covering to become a “foreign substance” to other types of cells in the future
and with strong international academic cooperation with Paris Research Center Cardiovascular (PARCC), France and related research institutions in the United States and Japan Therefore, there is an exchange of new technologies. To be used in engineering important parts that can create the desired biomolecules, it has been successfully performed at the animal level. Before expanding the results to study various related factors.
and preparing to develop it into the treatment of patients with cardiovascular disease Alzheimer’s disease and the next stroke, which is expected to be completed and filed for intellectual property registration. and publish their work in international academic journals. before transferring technology to Department of Medical Sciences to GMP standard production within approximately the next 3 years.
Mahidol University Ready to perform the duties of “wisdom of the land” according to the aspiration of Mahidol University. and to achieve the goals for sustainable development of the United Nations SDG3: Good Health & Well -being by adhering to the mission of being a “Healthy University” for the Thai people. and mankind
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