2023-06-17 07:00:00
Books by Hussam Al-Shaqwiri
Saturday, June 17, 2023 10:00 AM
While type 1 and type 2 diabetes are well defined, there is no strong definition of type 3 diabetes. Some people refer to it as the development of type 2 diabetes, in other words. diabetes Type 3 is a condition proposed for Alzheimer’s disease caused by insulin resistance in the brain. As a result, you might call it “brain diabetes,” according to the helpguide.com.
Because type 3 diabetes is a progression of type 2 diabetes, you can consider type 2 a risk factor. According to a study, people with type 2 diabetes are 60% more likely to develop type 3 diabetes than individuals with normal blood sugar levels.
Other causative factors for type 3 diabetes include:
Insulin resistance
Insulin resistance (IR) is a condition in which cells fail to respond to insulin. As a result, it reduces the body’s sensitivity to insulin. Type 3 diabetes is a condition that can follow following insulin resistance is initially diagnosed.
Insulin resistance causes a lack of glucose in the nerve cells of the brain. Glucose deficiency particularly affects the hippocampus and cerebral cortex of the brain, leading to type 3 diabetes.
Increase diabetes level in the blood
In some people, hyperglycemia, or high blood sugar, contributes to oxidative stress within the brain. Oxidative stress creates an imbalance of free radicals in the brain, which leads to tissue and cell damage. As a result, it causes cognitive degenerative type 3 diabetes.
lipid peroxidation
Lipid peroxidation is a chain of lipid degeneration in patients with type 2 diabetes. It causes cell destruction and oxidative stress, which is usually responsible for triggering type 3 diabetes.
The link between type 3 diabetes and Alzheimer’s disease
Type 3 diabetes is caused by insulin resistance in the brain. Here, only a limited amount of glucose is able to pass from the blood into the brain.
This insufficient amount is unable to fully power neurons and brain cells, depriving them of energy and is a major feature of Alzheimer’s disease, and this also leads to a progressive decline in memory, reasoning, and judgment.
A study showed that type 2 diabetes acts as a catalyst in the pathogenesis or development of type 3 diabetes or Alzheimer’s disease. At the same time, the results showed that significant activation of inflammatory mediators, oxidative stress, DNA damage, and mitochondrial dysfunction with insulin resistance leads to Alzheimer’s disease. .
Many people with type 2 diabetes do not know they have the condition, which delays diagnosis and appropriate treatment measures. As a result, untreated diabetes can damage the blood vessels in your brain over time. Eventually, people enter a type 3 state and develop dementia-like symptoms.
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