2023-08-04 15:28:57
The Spike protein of SARS-CoV-21 Omicron BA.1 carries 32 mutations compared to the ancestral strain (Hu-1) originally identified. These mutations significantly alter neutralizing antibodies induced by natural SARS-CoV-2 infection and/or vaccination with an encoding mRNA vaccine.
Immune memory is a mechanism that protects individuals once morest reinfection. This defense strategy of the body, which is the basis of the success of vaccines, includes the production of protective antibodies in the blood (detected by serology) as well as the formation of memory cells (memory B lymphocytes2), capable of reactivating quickly into antibody-producing cells upon re-infection.
The scientific literature has already shown that the repertoire of memory B cells generated by two or three doses of mRNA vaccines contains neutralizing clones once morest all variants of SARS-CoV-2 up to Omicron BA.1.
This study reveals that infection with the Omicron BA.1 variant mainly mobilizes memory B cells recognizing common proteins between the initial Spike protein and Omicron BA.1 already present in the repertoire formed following vaccination, but few cells directed once morest specific BA.1 mutations.
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