2023-08-09 10:18:41
Evidence from brain scans of 1,351 people showed that most overweight people had changes in their brain that made it difficult for them to know when they were full.
The researchers found that those who are overweight or obese have a greater hypothalamus than others, and the hypothalamus is known as a key area of the brain related to appetite regulation, as reported by Russia Today, quoting the Daily Mail. British.
The results of the MRI scan suggest that overweight people have three enlarged regions in the hypothalamus involved in picking up signals from the gut to say, “You’re full, stop eating.”
And this expansion may prevent the signals from getting through properly — so dieting is really harder for people who are overweight.
Dr Stephanie Brown, who led the study from the University of Cambridge, said: ‘This research helps us understand more about changes in the brain that occur in people who are overweight or obese – our brains and our biology may make it difficult for weight loss. As we see in mice as in humans, eating a high-fat diet can lead to inflammation in our appetite control center.Over time, this will change our ability to know when we’ve eaten enough and how our bodies process blood sugar, leading to us to gain weight.
The many hormonal signals sent from the gut to the brain that tell us when we are hungry and full are known to be moods. Lack of sleep, for example, disrupts the system and makes us feel hungrier than we should be.
“Hungry” and “full” hormone signaling may also be disrupted due to a larger hypothalamus.
Rat studies also reveal that being overweight causes the hypothalamus to swell in the first place – and this happened after just three days on a high-fat diet.
And if this is also the case in humans, they could be trapped in a vicious circle, where overweight people end up with a larger hypothalamus, which leads them to overeat, which leads to a change in the hypothalamus. more, so they eat more.
But the human study didn’t directly show this, which means more research is needed.
The researchers wanted to know if changes in the hypothalamus of overweight people were caused by their diet stimulating immune chemicals that then build up at the barrier that separates the brain from the rest of the body.
This can cause glial cells to build up in the brain, which leads to waste disposal, which can then damage healthy cells, making the hypothalamus less able to receive ‘hunger’ and ‘satiety’ signals from hormones in the gut.
The study looked at people between the ages of 18 and 40, and compared the brains of those who were a healthy weight, overweight, or with a BMI over 25, or obese with a BMI over 30. It turned out that the higher the BMI , the volume of the hypothalamus increased.
The hypothalamus, which is about the size of an almond, is usually very difficult to see on an MRI machine, as the brain tissue it contains is very similar, so there is not much light or shadow in a brain scan.
But the researchers used a high-tech algorithm that makes the vision clearer by identifying different cell types.
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