2024-01-16 16:37:32
New insights into the genetic causes of Parkinson’s
A team of scientists from Saarland University led by Prof. Rita Bernhardt has now gained new insights into the genetic causes of Parkinson’s disease. The researchers found that in people with a genetic predisposition to Parkinson’s, additional changes in the cytochrome P450 genes can trigger the disease.
Cytochrome P450 enzymes are involved in a variety of metabolic processes, including the breakdown of drugs and toxins. The scientists suspect that the altered cytochrome P450 enzymes impair the function of nerve cells in the brain and thus contribute to the development of Parkinson’s disease.
The results of the research might help to develop new, causal therapies for Parkinson’s disease.
Even more knowledge from research: Eye scans can detect the first symptoms
Through the use of eye scans, Parkinson’s might be detected significantly earlier, on average seven years before the first occurrence of the symptoms. This is emphasized by researchers in a study published in the journal “Neurology”.
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In a cross-sectional analysis of two separate studies, the researchers have now identified signs of Parkinson’s in eye scans. To detect the markers in the retina, they analyzed information from around 155,000 patients aged at least 40 who visited eye clinics in London between 2008 and 2018. In parallel, data from approximately 67,300 healthy volunteers aged 40 to 69 years were used to examine the temporal relationship of markers to symptom onset. The results suggested that People with Parkinson’s have a reduced thickness of the retinal nerve fiber layer and the inner granular layer in the eye.
More on this topic: Parkinson’s: recognizing signs and early symptoms >>
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