2024-02-01 03:02:13
In the attempt, 93.5% of the proteins encoded by the human genome were identified.
The UNAM participates in the international initiative Human Proteome Project, which seeks to identify, characterize and localize the proteins encoded by the human genome, through Chromosome Centric Human Proteome Project (C-HPP).
The scientists who collaborate on it worldwide identified 25 percent of the total proteins by going, in the 12 years that this project has been in operation, from 13,588 to 18,467, achieving 93.5 percent of the Human Proteome.
This is its great merit. “In addition to knowing how these proteins are expressed, we also know how they behavewhat modifications they have,” said researcher Sergio Manuel Encarnación Guevara, founder and head of the Proteomics Laboratory of the Center for Genomic Sciences (CCG) of the UNAM, headquarters of the Mexican consortium that intervenes in the World Organization Human Proteome project ( HUPO, for its acronym in English).
The C-HPP of the HUPO, explained the also doctor in Biomedical Research, is made up of a consortium of 25 groups that bring together more than 400 scientists from 20 countries whose mission is to study each of the 24 human chromosomes and the mitochondrial genome. , especially proteins or gene products.
“The objective is find rigorous evidence for all encoded proteins by the human genome. That is, if we have more than 19,500 genes, find at least one protein of each of these in some part of the human cell or tissue,” added the also member of the National System of Researchers level III.
These works began in 2011 and the National University joined in 2018. Mexican scientists together with colleagues from Canada, the United States and Brazil – which are the only ones cooperating on the American continent – have focused on identifying and assigning function to the proteins of the chromosome 19.
“When we started working with this chromosome, there were 16.6 percent unidentified proteins, that is, It was not known what proteins that percentage of genes encoded.. Currently regarding 5.5 percent remain. We have made important progress and much has been contributed by the Mexican consortium,” said the expert.
The project is scheduled to conclude in 2028. “The challenge we have before us is important because the proteins that remain are increasingly difficult to locate, since we must do so in poorly studied conditions, such as in rare diseases, because perhaps there we will find the expression of that gene. and its product: protein,” explained the university student.
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