The body of Brianna Ghey, who was stabbed to death, was found in a park in Culchet near Liverpool in north-west England on Saturday.
A 15-year-old girl and a boy of the same age have been charged, Cheshire Police said on Wednesday. They will appear in court at a later date.
Investigators are now looking into whether Brianna Ghey was killed because she was transgender.
Hassan and Said prosecuted for the rape of a young transgender man
On Wednesday, new rallies were held in several cities across the country by the transgender community, following candlelight vigils held the day before in Liverpool and Bristol.
This murder comes at a time when the issue of transgender people has been at the heart of culture wars in the United Kingdom for several years, giving rise to heated debates.
In a statement sent by the police, the victim’s family paid tribute to a “beautiful, witty and hilarious” young girl. “Brianna was strong, fearless and unique,” they added, her passing “leaves a huge hole in our family.”
On Monday, many of Brianna’s classmates laid flowers at the entrance to the police-blocked park where her body was found.
A fundraiser organized to help his family had raised more than 92,000 pounds sterling (103,000 euros) on Wednesday.
