2023-05-19 00:24:09
The joint research team of France’s National Center for Scientific Research, Paris City University, and Australia’s University of Queensland conducted an experiment in transplanting human liver cells into the liver of mice in the scientific journal ‘Science Advances’ on the 18th. He said that he confirmed the phenomenon of the degree of advance.
All organisms regulate their activities during the day according to the internal clock known as the ‘circadian biological clock’. It is known to act on signals.
In this study, the research team created a chimera mouse model in which human hepatocytes were transplanted into the liver of mice, observed behavioral changes, and confirmed that the daily cycle of mice, which are normally nocturnal, was advanced by 2 hours.
The chimera mice transplanted with human hepatocytes showed partially diurnal animal-like behavior, such as actively feeding from two hours before sunset.
The research team seems to have changed the circadian rhythm of mice due to the influence of transplanted human hepatocytes, which means that hepatocytes can affect the entire circadian rhythm and physiological activities of animals, including the peripheral circadian clock.
Then, changes in the liver circadian clock caused by pathological causes, such as cirrhosis, can also affect the synchronization function of the central circadian clock, suggesting that it affects the entire circadian rhythm, including sleep and wake cycles, and can also cause metabolic diseases. pointed out that
However, the research team said that it was not clear which hormones and neural mechanisms act between the brain, liver, and peripheral circadian clock to regulate and synchronize circadian rhythms, and that follow-up studies are needed.
“Liver disease, metabolic diseases such as diabetes and obesity are related to sleep disorders, irregular meals, and circadian rhythm disturbances,” said University of Queensland Professor Frederic Gaschon, co-corresponding author of the paper. “This study will contribute to the search for new treatments for metabolic diseases.”
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