2023-11-14 08:43:06
Predicting toxicokinetics and toxicity using open access software
Scientists from EFSA and several leading European research organizations have joined forces to create “TKPlate”. It is an online platform that provides scientists and regulators with a dedicated space and a suite of tools to model and predict the toxicokinetics and toxicity properties of chemicals.
Two senior EFSA scientists – toxicologist Jean-Lou Dorne and statistician/modeler Jose Cortiñas Abrahantes – are leading this work.
Jean-Lou: “The idea of TKPlate was born in 2014, with a scientific report on alternative methods to animal testing that could be used by EFSA experts. The report proposed developing a series of toxicokinetic and toxicodynamic models. Toxicokinetics tells us how the body absorbs, distributes, metabolizes and excretes chemicals. Toxicodynamics explores the toxic effects on molecules, cells, tissues, organs or an entire organism.
Jose: “Between 2015 and 2020, EFSA focused on developing these toxicokinetic models and produced numerous case studies for a series of species A subdivision of the genus, species is a group of closely related and similar-looking organisms; for example, in the case of Homo sapiens (humans), the second part of the name (sapiens) designates the species. relevant to EFSA’s work: humans, laboratory animals such as rats and mice, farm animals and other species that play a role in the human and animal food chain, e.g. earthworms . We have entrusted academic partners and national agencies with a significant part of this work, which has resulted in several successful doctorates from young scientists.”
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