2024-08-27 04:15:00
Do you feel like your body is declining? It doesn’t have to be just a feeling. Scientists from Stanford University in the US and Nanyang Technological University in Singapore followed 108 US participants for several years to look at aging-related changes in different molecules.
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Scientists have discovered that there are two stages of aging that occur at certain ages. “The analysis revealed a consistent nonlinear pattern in the molecular markers of aging, with severe dysregulation occurring at two major periods around age 44 and age 60,” the authors of the study published in science magazine natural aging. Previously added: “Unique molecular and functional pathways associated with these periods have also been identified, such as changes in immune regulation and carbohydrate metabolism during the 60-year transition, and cardiovascular disease metabolism, lipids, and Alcohol changes »
Therefore, the authors believe that human aging does not occur in a gradual, linear manner across the lifespan. Instead, the different molecules the researchers examined experienced accelerated changes at ages 44 and 60. exist CNNMichael Snyder, chairman of the Department of Genetics at Stanford University and author of the study, gave some examples. He explains that the ability to metabolize caffeine decreases around age 40, and then decreases again around age 60. Likewise, components involved in alcohol metabolism decrease around age 40. In total, 81.03% of the molecules (9,106 out of 11,305) showed changes in at least one of the two identified phases.
A common process for men and women
“People often experience muscle damage and fat accumulation (related to lipid metabolism) in their 40s, and sarcopenia (muscle loss) definitely occurs in their 60s – it’s a very serious problem, ” Michael Snyder added. Additionally, the study’s authors report that the risk increases more rapidly after age 60.
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In fact, the study concluded that people aged 60 or older are more likely to develop cardiovascular disease, kidney problems and type 2 diabetes. .
Around the age of 55 is a turning point
As part of the study, researchers observed a transition point around age 55. This shift is not only attributed to women’s menopause but also represents a common phenomenon in the aging process for both sexes. “This result is consistent with previous research and further supports the idea that this transition point is a major feature of human aging,” confirm the authors.
However, they caution that further research is needed to validate these first elements: “These results demonstrate the potential usefulness of these data sets as indicators of aging processes, while recognizing that additional studies are needed for validation. »
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