2024-03-28 16:56:00
Researchers at the University Hospital in Copenhagen, Denmark, have found that the use of drugs aimed at treating gastrointestinal diseases, known as proton pump inhibitors (PPIs), may increase the likelihood of developing dementia. The results of this study were published in the journal Alzheimer’s & Dementia (A&D).
Proton pump inhibitors (PPIs) are a group of medications that reduce the production of stomach acid. To assess the long-term effects of their use, the researchers conducted a study of 983,785 people aged 60 to 75 who did not have dementia and were not taking cognitive-enhancing drugs.
After collecting health information from the participants, an 18-year follow-up period began.
During follow-up, 99,384 participants were diagnosed with dementia. Among those who experienced the disease, regarding 21.2% were taking at least two PPI drugs, compared with 18.9% of healthy participants. The researchers noted that the likelihood of severe cognitive impairment was highest in those participants who had used proton pump inhibitors for more than 15 years.
In addition, participants aged 60 to 69 years who regularly used PPIs were more likely to develop dementia.
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