2024-06-01 04:53:26
▲ Analysis outcomes present that the “ketogenic weight-reduction plan”, which is called a weight-reduction plan, accelerates cell ageing. (Photograph = DB)
[메디컬투데이=이승재 기자] The findings counsel that the “keto weight-reduction plan,” also referred to as a fasting weight-reduction plan, can speed up mobile ageing.
The outcomes of the mouse experiments inspecting the consequences of the ketogenic weight-reduction plan on mobile ageing had been printed in Science Advances.
Weight problems is taken into account a critical public well being downside in america. Due to this fact, weight-reduction plan meals that assist shed some pounds have gotten more and more widespread. A consultant weight-reduction plan meals is the “ketogenic weight-reduction plan.” The ketogenic weight-reduction plan was initially developed to deal with epilepsy and is characterised by low carbohydrate content material and excessive fats content material.
The researchers studied the consequences of the keto weight-reduction plan on mobile ageing utilizing mice. The mice within the experimental group ate a low-carb, high-fat weight-reduction plan known as “Crisco.” Of the overall energy in Crisco, 90.5% got here from fats, 9.2% got here from protein, and 0.3% got here from carbohydrates.
Management mice adopted an everyday weight-reduction plan by which 17% of complete energy got here from fats, 25% from protein, and 58% from carbohydrates.
The outcomes of the research confirmed that the ageing of cells in main organs reminiscent of the guts and kidneys of the experimental group of mice that consumed Crisco was accelerated. Histological evaluation confirmed that the guts, liver and kidney tissues of the experimental group of mice had been filled with “senescent cells” that had stopped dividing however had not died.
In keeping with the Nationwide Institutes of Well being (NIH), mobile senescence refers back to the damaging course of that results in multi-organ illness or ageing.
If senescent cells don’t die, they’re susceptible to irritation or organ harm, resulting in tumors. As well as, molecular organic evaluation confirmed that “AMPK” and “p53” proteins are concerned within the cell ageing course of.
By blocking the biochemical pathways related to these proteins, the mice’s mobile senescence ranges returned to their earlier ranges. Likewise, when the Crisco weight-reduction plan was stopped, the mice’s mobile senescence ranges had been alleviated.
The researchers clarify that whereas the ketogenic weight-reduction plan does enhance the speed of mobile ageing, the speed of mobile ageing may be slowed down just by utilizing medication that block particular proteins or by decreasing the ketogenic weight-reduction plan. Primarily based on these outcomes, they conclude that the keto weight-reduction plan accelerates mobile ageing.
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