How is Omikron BA.4 and BA.5 going into the lungs like a delta? how dangerous
What is Omikron BA.4/BA.5?
However, BA.4 and BA.5 have distinctive characteristics that are different from BA.2 as follows:
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There is a mutation in the L452R location, which is the same location where the mutation is found in the delta species.
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Has the ability to spread infection faster
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more resistant to human immunity
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more drug resistance
What are the symptoms of Omikron BA.4/BA.5?
Symptoms of Omikron BA.4 and BA.5 from the present data are not very different from other species of Omikron, mainly fever, sore throat, cough, runny nose, etc.
Dr. Anan Chongkaewwatana revealed the symptoms of Omikron BA.1, BA.4 and BA.5 cases collected by the French Public Health Service. It was found that overall patients infected with BA. 4 and BA.5 were more pronounced than the first omikron addicted patients. The symptoms that are found in more than 50%, respectively, are:
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fatigue
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cough
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have a fever
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headache
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runny nose
In addition, respiratory symptoms such as shortness of breath and difficulty breathing were also found. including gastrointestinal symptoms such as diarrhea in BA.4 and BA.5 patients more than the original omikron strain.
Symptom Omicron BA.4/BA.5
Will it be severe or will it go into the lungs?
As you know, subspecies BA.4 and BA.5 can evade immunity well. It also mutates in the same position as the Delta species. So people are worried that if the infection comes up, there will be severe symptoms. Or infect the lungs like the delta?
regarding this issue Department of Medical Sciences provided information that From laboratory research, it was found that BA.4 and BA.5 can damage the lungs and cause pneumonia more easily. But the clinical data is insufficient evidence to definitively tell the severity of the disease. So don’t panic and worry too much.
In line with Assoc. Prof. Dr. Jesada Denduangboriban Lecturer at Department of Biology Faculty of Science Chulalongkorn University The Facebook post states that A concern for BA.4 and BA.5 is a mutation in the spiny protein gene L452R that makes it easier to infect human cells. May infect more lung tissue And experiments in hamsters showed that BA.4 and BA.5 can cause severe illness. But there is no evidence in humans. However, from the information available at present, there is no indication that BA.4 and BA.5 will cause a severe epidemic and cause many deaths.
As for Prof. Dr. Prasit Wattanapha, Dean of the Faculty of Medicine Siriraj Hospital Mahidol University also commented in the same way that The BA.4 and BA.5 subspecies multiply faster. and more lung cell islands than BA.2, but not to the delta. And at the moment there is no evidence that BA.4 and BA.5 cause sickness to the point of hospitalization. or have severe symptoms until death
Keep an eye on the BA.5 subspecies. that is 3 times more resistant to immunity
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Dr. Teera Woratanarat Faculty of Medicine Chulalongkorn University revealed that the BA.5 subspecies has the ability to dodge immunity. or resistant to immunity 3 times more than a senior like BA.1 and may have the ability to multiply higher than all species
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in the medical genome center Faculty of Medicine Ramathibodi Hospital Mahidol University (Center for Medical Genomics) states that in the United States, omicron BA.5 has a higher epidemic rate than BA.2, while in England BA.5 has a faster growth rate than BA.2, regarding 35.14% and believes that Thailand is likely to have a gradual outbreak of BA.5 to replace all species because it can spread faster than BA.2, but the severity and clinical symptoms should be no different from BA.2.
- while the World Health Organization commented that BA.5 should be closely monitored because antibodies that destroy the activity of the pathogen are less active. less responsive medication But it was not conclusive whether there was an increase in violence or not.
If you have been infected with covids, you have the right to be infected once more.
People who have previously been infected with COVID-19 despite having natural immunity But still infected with covids BA.4 and BA.5 once more because this species is resistant to the immune system. and can dodge the landscape The existing landscape may not be sufficient to prevent re-infection. especially in people who are not vaccinated or did not receive all 3 doses of vaccination, it will be a group that is easily infected or has a higher chance of recurring covids than those who have been vaccinated.
Therefore, the Department of Medical Sciences Therefore, it is recommended to increase the booster vaccination as a 4th dose because there are foreign data that show that BA.4 and BA.5 strains if received the booster vaccination will have less symptoms than those who did not. This means that the vaccine is also effective in preventing serious illness and death.
Consistent with the information from Prof. Dr. Yong Phuworawan, head of the center specializing in virology. Clinic, Department of Pediatrics Faculty of Medicine Chulalongkorn University who posted the Facebook fan page that The appearance of COVID-19 is likely to resemble the flu. With mutations that can avoid immunity continually, we have to vaccinate each year to stimulate immunity.
However, it must be emphasized once more that we should protect ourselves in the first place as best as possible. both wearing masks Washing your hands often because covid 19 is not over yet. Importantly, vaccinating once morest covids will help reduce the severity of the disease. especially in different risk groups
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