People suffering from infections requiring specialized hospital care during youth or middle life […]
The people that suffer from infections that require specialist hospital care during youth or middle life have a higher risk of Alzheimer’s y Parkinsonbut not Amyotrophic Lateral Sclerosis o IS IT OVER THERE.
This is the main conclusion of a study published in PLOS Medicine and carried out by scientists at the Karolinska Institute, in Sweden.
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Although previous animal studies have suggested that infections play an important role in the development of some neurodegenerative diseaseshuman trials remain scant.
In the new study, researchers analyzed data from people diagnosed with Alzheimer, Parkinson o ALS between 1970 and 2016 in Swedenidentified from the Swedish National Patient Registry.
The analysis included 291 thousand 941 cases of Alzheimer’s, 103 thousand 919 Parkinson’s y 10 thousand 161 from ELA.
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Hospital infections increase risk of Alzheimer’s and Parkinson’s
suffer a infection (viral or bacterial) in the hospital five or more years before diagnosis was associated with a 16% increased risk of Alzheimer’s; and a 4% increased risk of Parkinson’s.
The highest risk of disease was detected in people who had been treated for infection repeatedly before their 40th birthdaywith a more than doubled risk of Alzheimer’s and a more than 40% increased risk of Parkinson’s.
No association was observed with ALS, regardless of age at diagnosis.
“These findings suggest that infectious events may be a trigger or amplifier of a pre-existing disease process; leading to clinical onset of neurodegenerative disease at a relatively early age,” say the authors.
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However, he notes, “due to the observational nature of the study, these results do not formally prove a causal relationship.”
“Infections treated in the hospital, especially in the early and middle ages of life; were associated with an increased risk of Alzheimer’s disease and Parkinson’s disease. Mainly among people diagnosed before the age of 60″, concludes Jiangwei Sun, lead author of the study and researcher at Karolinska.
With information from EFE