Scientists of hairless mice Long lifeY to other genes linked to Mice I have succeeded in transferring.
This is a breakthrough that has led to better health and longevity in mice.
Researchers have long studied hairless mice for their longevity and unusual resistance to related diseases.
According to research recently published in the journal Nature, a specific gene responsible for better cell repair in hairless mice was transferred to other mice.
As a result, the average lifespan of these mice increased by about five percent and overall health improved.
The scientists, including scientists from the University of Rochester in the US, say that these findings open the way to unraveling the mysteries of aging and the exciting possibilities of extending human lifespan.
Research Co-author Vera Gorbonova says: ‘Our research provides proof of principle that unique longevity mechanisms evolved in long-lived mammals can be transferred to other mammals for longevity. is.’
Scientists have successfully transferred a gene into mice, which produces the high molecular weight hyaluronic acid (HMW-HA).
It’s a molecule that gives hairless mice exceptional resistance to cancer.
A previous study reported that hairless mice had 10 times more HMW-HA in their bodies than mice and humans, and when the molecule’s gene was removed from the mice’s bodies, their The cells are more likely to become cancerous.
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In the new study, scientists genetically modified mice to produce the hyaluronan synthase-two gene found in hairless mice.
This gene is responsible for making the protein that produces the HMW-HA molecule.
Mice that had the same gene as hairless mice were better protected against both spontaneous tumors and chemical-induced skin cancers, the scientists said.
The researchers said that the overall health of the genetically modified mice also improved. They live longer than normal mice.
The study found that these mice also had less inflammation in different parts of the body, indicating slower aging and a relatively healthy digestive system.
According to the researchers, the new discovery could lead to new possibilities for improving aging and reducing inflammation in humans.
According to Andrey Sullivanov, another author of the study: ‘We have already identified molecules that slow down the degradation of hyaluronan and are testing them before clinical trials.’
Dr Sullivanov said: ‘We hope our results are the first but not the last example of how animal longevity techniques can be used to help humans live longer and healthier lives. ‘
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#Successful #transfer #longevity #genes #mice #Scientist
**Interview with Dr. Vera Gorbonova on Longevity Gene Transfer in Mice**
**Interviewer:** Thank you for joining us today, Dr. Gorbonova. Your research on the longevity gene transfer in mice is groundbreaking. Can you explain a bit about how this gene transfer works and its significance?
**Dr. Gorbonova:** Thank you for having me. Essentially, we have focused on a gene that produces high molecular weight hyaluronic acid, or HMW-HA, which is responsible for the longer lifespans and better health observed in hairless mice. By transferring this gene to other mice, we’ve been able to increase their average lifespan by about five percent and improve their overall health. This is significant as it demonstrates a proof of concept that longevity mechanisms from long-lived mammals can indeed be transferred.
**Interviewer:** That sounds remarkable! What specific benefits did the modified mice exhibit after the gene transfer?
**Dr. Gorbonova:** The modified mice showed remarkable resistance to cancer, as HMW-HA plays a crucial role in cell repair and cancer resistance. In our studies, we found that hairless mice had ten times more HMW-HA compared to regular mice and humans, which underlines its importance. When we removed the gene that produces HMW-HA, those mice’s cells became more susceptible to cancerous changes.
**Interviewer:** This research seems to open many doors to understanding human aging. What are the next steps for your team in exploring these findings?
**Dr. Gorbonova:** Yes, absolutely. Our next steps will involve deeper investigations into how the transfer of such genes could impact human health and longevity. We also hope to explore potential therapeutic applications that can reduce inflammation-related diseases in humans, which would align with our goal of extending healthy lifespan.
**Interviewer:** It’s exciting to think about the implications of your work! As you move forward, how do you view the ethical considerations surrounding such genetic modifications?
**Dr. Gorbonova:** Ethical considerations are crucial in genetic research. While our findings have exciting potential for improving health and longevity, we must approach these possibilities cautiously. It’s important to ensure that any applications in humans are safe, ethical, and developed through thorough research and regulatory oversight.
**Interviewer:** Thank you, Dr. Gorbonova, for sharing your insights with us today. We look forward to seeing how your research progresses!
**Dr. Gorbonova:** Thank you for having me! I’m excited about the future of this research and its potential impacts on health and longevity.
