2024-08-25 17:18:15
One of the major challenges in medicine is preventing the development of Alzheimer’s disease, or the severe dementia associated with aging. However, a possible answer to this challenge comes from an unexpected drug: a labor-inducing drug thought to hold promise in preventing the buildup of toxic waste in the brain that can lead to cognitive decline.
Generally speaking, Alzheimer’s disease is caused by a buildup of proteins in the brain that become tangled and unable to be eliminated, stressing the organ and reducing its processing capacity. In addition, they release toxins that accelerate organ deterioration.
A study in mice by researchers at the University of Rochester in the US showed that small doses of prostaglandin hormones – labor induction agents – do not cause uterine muscles to contract, but rather cause the neck lymphatic muscles to contract . Drains toxic substances that accumulate in the brain. As a result, the organ appears to stay healthy longer and has a lower risk of developing dementia.
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The survey was published in the journal Science on August 15 natural aging It is carried out in two stages. The first compared lymphatic vessel function in young and old rats. Older adults filter liquids 63% slower.
In the second phase, the scientists analyzed two groups of aged rats: the first group received varying doses of prostaglandin to study its effects on brain hygiene, and the second group received no drug.
Using hormones can “restore” the function of the valves, allowing them to work at a similar rate to that of young mice, thereby reducing the risk of Alzheimer’s disease and even serving as a treatment for early-stage dementia.
Because humans have a similar valve system that filters brain fluid about three times a day, doctors believe the findings in mice can be replicated in humans in the future.
“Unlike the cardiovascular system, which has one big pump — the heart — fluid in the lymphatic system is transported through a network of smaller pumps,” said Douglass, professor of biomechanical engineering and leader of the study. Douglas Kelley explained. “These blood vessels are close to the surface of the skin and are distributed throughout the neck. We know they are important, and now we understand how to speed up this function. This may even form the basis of future treatments for neurodegenerative diseases,” he said in an interview on the university’s website .
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Alzheimer’s disease is a degenerative disease caused by the death of brain cells that may appear decades before the first symptoms appear.
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Because the disease tends to worsen over the years, early diagnosis is crucial to slowing its progression. Therefore, when symptoms of any disease appear, it is necessary to consult a specialist.
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While these symptoms are more common in people over the age of 70, it’s not uncommon to see them in younger people around the age of 30. In fact, when this “premature” presentation occurs, the condition is called Early-onset Alzheimer’s disease.
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In the initial stages, people with Alzheimer’s disease often experience changes in their memory and begin to forget simple things such as: where they put their keys, what they had for breakfast, someone’s name, and even the season of the year.
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Disorientation, difficulty remembering the address where you live or directions home, and difficulty making simple decisions such as planning what you will do or what you will eat, are also signs of the disorder.
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Additionally, loss of the desire to perform daily tasks, behavioral changes (making the person more nervous or aggressive), and repetition are some of the most common symptoms.
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According to research conducted by the Alzheimer’s Drug Discovery Foundation (ADDF), the presence of damaged proteins (amyloid and tau), vascular disease, neuroinflammation, neurological and genetic energy failure (APOE) may contribute to the development of the disease. related.
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Treatment for Alzheimer’s disease includes the use of medications to reduce symptoms of the disease, in addition to physical therapy and cognitive stimulation. This disease cannot be cured and must be carefully cared for until the end of life
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