2023-05-12 08:34:51
Although desensitization to allergens is the most widespread treatment, a vaccine is being developed to treat pollen allergy.
The return of spring is synonymous for those allergic to pollen with the resumption of treatments. If alternatives are put in place to facilitate their daily lives, such as allergen weather, this is not enough. But today it is impossible to permanently cure this allergy.
Treatments exist such as desensitization. But the latter only helps to better support the significant presence of pollen in the air. Researchers are therefore working on the development of a vaccine capable of completely curing this disease.
Moreover, these do not only concern pollen. Vaccines are being developed to treat allergy to dust mites, animal hair, peanuts… And in this field, one of the working groups of the Institut Pasteur in Paris is in the process of proposing two clinical trials for two allergy vaccines.
A duo of vaccines to be administered together to treat the origin of the problem
The team has been working on the development of this vaccine for several years now. In 2021, a preparatory study involving tests on mice had also been shared in the journal Nature Communications. It was regarding the allergic asthma treatment. But its operation is very close to a treatment once morest traditional allergies.
The researchers explain that each allergy originates from an abnormal production of IgE antibodies and interleukins IL-4 and IL-13. In fact, they want to create two vaccines capable of promote the production of antibodies and therefore protect the body once morest pollen. During the test carried out on mice, the researchers noticed better antibody production and real lasting protection even one year following the injection.
In view of these satisfactory results, the Institute is preparing to conduct clinical trials on human patients. Preparation of vaccine doses is underway and the trial should begin in 2024.
When might this pollen allergy treatment be offered to patients?
However, the researchers already think that these vaccines will have to be subject to regular booster shots. According to their first estimates, the persons concerned should have need a new injection every 2 or 5 years. However, this estimate remains hypothetical. It is first necessary to determine the clinical effectiveness of the vaccine once morest allergy to pollen before establishing a vaccination record.
But scientists are confident. If the tests go smoothly, they believe that this duo of vaccines might be administered from the year 2030.
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