2023-05-15 02:01:48
Correlation with sleep revealed
Peripheral arterial disease (PAD) is a condition in which the arteries in the legs become blocked, reducing blood flow and increasing the risk of heart attack or stroke, affecting more than 200 million people worldwide.
A study by the Karolinska Institute in Sweden found that people who slept less than 5 hours a night were 74% more likely to develop PAD than those who slept 7 to 8 hours. “Our study suggests that sleeping 7 to 8 hours a night is a good habit for lowering the risk of PAD,” said study author Dr. Shuai Yuan.
It has been previously known that not getting enough sleep at night and napping during the day is associated with an increased risk of coronary artery disease. And sleep problems are one of the top complaints from patients with PAD. The new study aims to fill the gap in the lack of data on the relationship between sleeping habits on PAD and vice versa.
The study was conducted with more than 650,000 participants. First, the research team analyzed the association between sleep duration and daytime napping and the risk of PAD. In addition, genetic data were used to investigate causal relationships in Mendelian randomized studies.
A synthesis of the experiments showed that the relationship between short sleep and PAD was established in both directions. In an observational analysis of 53,416 adults, sleeping less than 5 hours a night was associated with an almost double increased risk of PAD compared to sleeping 7 to 8 hours. This finding was supported by additional analyzes of 150,000 and 450,000 people, respectively.
In a causal study, short sleep was associated with an increased risk of PAD, and additionally PAD was shown to be associated with an increased likelihood of short sleep. “This suggests that sleeping shorter periods of time at night may increase the chance of developing PAD, and having PAD increases the risk of getting insufficient sleep,” explained Dr. Yuan.
In an observational analysis of 50,000 people, the risk of PAD was 24% higher when sleeping for 8 hours or more compared to sleeping 7 to 8 hours. These findings were supported by analyzes of larger populations. However, no causal relationship was found between long sleep and PAD.
Those who napped had a 32% higher risk of PAD compared to those who did not nap. However, no causal relationship was found.
“More research is needed on how to counteract the bidirectional relationship between short sleep and PAD,” said Dr. Yuan. “Lifestyle changes that help people get more sleep, such as being physically active, can reduce the risk of developing PAD. It can be lowered,” he said. And for patients with PAD, optimizing pain management can help them get a good night’s sleep.
The study was published in the European Heart Journal Open. The original title was ‘Sleep duration, daytime napping, and risk of peripheral artery disease: multinational cohort and Mendelian randomization studies’.
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