2023-07-06 08:05:52
In people with a depressive disorder, lack of sleep might have beneficial effects. Indeed, according to an American study conducted by researchers from the Perelman School of Medicine, University of Pennsylvania, Philadelphia, sleep deprivation might improve the mood of patients suffering from depressive disorders. These findings were published in the scientific journal PNAS.
“The study reveals that a night of total sleep deprivation improved connectivity from the amygdala to the anterior cingulate cortex, which was correlated with better mood in some healthy and depressed individuals,” the study release reports. This experiment was conducted on healthy people, others with major depressive disorder, and a group that was allowed plenty of sleep. The experiments were performed in the laboratory of the Center for Translational Clinical Research at the University of Pennsylvania Hospital for five consecutive days. All volunteers underwent three resting-state MRI sessions over the five days.
An improved mood
This study found that most participants showed a deterioration in mood immediately following missing a night’s sleep. Connectivity from the amygdala to the anterior cingulate cortex increased significantly in patients whose mood improved, but less so in those whose mood did not. Thirteen of the 30 depressed participants (43%) experienced an improvement in mood, and the remaining 17 participants experienced worsening mood or no change.
“After a restful night’s sleep, 20 participants with major depressive disorder experienced an improvement in mood, and the remaining participants experienced worsening mood or no change,” the study reports. Before for the researchers to conclude: “This study highlights the key role of the cingulate amygdala circuit in the regulation of bad mood in healthy and clinical populations. Our results might have implications for the development of rapid and unique antidepressant interventions.”
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