2023-06-29 15:21:40
Why is this important?
Pulse pressure (PP), which reflects the difference in systolic (SAP) and diastolic (DBP) blood pressure values, increases with age, especially in women. It is a cardiovascular risk factor. However, the pathogenesis of this mechanism is not well described: studies that have looked at the more rapid increase in SBP and PP in women than in men following 40 years suggest a role for aortic stiffness and reflection of the premature wave, but they were transverse or had a short longitudinal tracking. This study has the advantage of providing hemodynamic measurements acquired over a period of 14 years. The authors hypothesized that sex differences in aortic stiffness contribute to differences in SBP and PP.
Methodology
This work was conducted using participants from three cohorts (Framingham 3rd cohort, Omni-2 and New Offspring Spouse). All those who were included participated in three medical visits with measurements of hemodynamic parameters at D0, at the 6th and then at the 14th year.
Principle results
A total of 4,595 people took part in the hemodynamic evaluation at the first visit, then 3,778 and 3,451 of them (mean age of 40.7, 46.9 and 54.4 years respectively).
SBP changed minimally across the entire age group between exams 1 and 2 and then moderately between exams 2 and 3, particularly in middle-aged and older women. The relationship between SBP and age was relatively flat until midlife and increased therefollowing, particularly in women. Mean and PAD pressures increased with age through midlife. Then, the PAD decreased.
At younger ages, blood pressure pulsatility was lower in women than in men. In the middle of life, it increased more in the former to exceed those noted in men. Pulse wave velocity was lower in females and increased with age at a steeper slope than in males. The women’s data also showed an earlier return of the retrograde wave and a greater increase in central pressure.
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#Evolution #pulse #pressure #age #gender
