A joint research team at Seoul National University Dental Hospital and Harvard Dental University suggested a way to shorten the implant treatment time.
Professor Young-Dan Cho (Department of Periodontology, Seoul National University Dental Hospital) and Professor William Giannoville (Dean, Harvard University) revealed this as a result of a study on the improvement of bone regeneration through dental implant surface bone morphogenetic protein (BMP) gene fixation technique.
Treatment methods using BMP (bone morphogenetic protein) are used in clinical practice so that the implant can adhere well to the gingival bone and are supplied in the form of protein. didn’t
A method using the BMP gene has been developed to ensure a stable supply of BMP and enhance the effect, but if the gene applied to the surgical site is not fixed, it flows through the blood to other tissues, causing serious problems in forming bones.
Accordingly, the joint research team conducted experiments in cell experiments and mouse implant models by fixing the BMP7 gene on the titanium implant surface using CVD (Chemical Vapor Deposition) technology.
As a result, it was verified that the BMP7 protein was stably produced on the surface of the BMP7 gene-coated titanium, and through this, it was confirmed that the differentiation of osteoblasts was enhanced and the bone regeneration ability was increased.
Professor Young-Dan Cho said, “It takes at least three months for bones to stably attach to the surface of titanium SLA (sandblasted, large grit, acid-etched), which is currently most used. It will be possible to reduce the discomfort of patients by shortening the period without teeth, and furthermore, the BMP gene fixation method can be applied to bone graft materials.”
This study was carried out with support from the National Institutes of Health in the United States and the Swiss Osteology Research Foundation, and was published in ‘Advanced Materials Interfaces (IF 6.147)’, a renowned international scientific journal in the field of materials, with the title of ‘BMP gene-immobilization to dental implants enhances bone regeneration’. It was published last June.
