Rising Cases of Syphilis with Unusual Symptoms: Vision Problems, Headaches, and Hearing Loss in Chicago

CHICAGO — Disease detectives in Chicago have made a concerning discovery – an increase in patients reporting unusual symptoms such as vision and eye problems, headaches, and hearing loss or dizziness caused by the sexually transmitted infection syphilis. While syphilis has long been known to cause permanent damage to vision and hearing, these symptoms are typically associated with untreated infections that have progressed over many years.

A recent study presented at the 2024 Epidemic Intelligence Service Conference in Atlanta sheds light on this emerging trend. Researchers found that there were over two dozen cases of syphilis-related symptoms in Chicago last year, with nearly a third of these cases in the early stages of infection. Surprisingly, more than two-thirds of these patients did not exhibit typical syphilis symptoms like a rash or chancre sore, making it more challenging for doctors to identify the infection.

Lead study author Dr. Amy Nham, a first-year EIS officer, or “disease detective,” assigned to the Chicago Department of Public Health, emphasizes the need for increased screening by healthcare providers to address this issue. She urges clinicians to be aware of these unusual symptoms and the changing landscape of syphilis infections.

Syphilis cases have been surging across the United States, with over 207,000 reported cases in 2022 – the highest number since the 1950s, according to the US Centers for Disease Control and Prevention (CDC). Traditionally, men who have sex with men have been most affected by syphilis, but the demographics of the infection have shifted in recent years, with the number of infections more than doubling in heterosexual men and women since 2019. Additionally, cases of congenital syphilis, where the infection is passed from a pregnant woman to her baby, are also on the rise.

Dr. Nham’s study focused on Chicago, but similar patterns are being observed in other parts of the country. It remains unclear why there is an increase in cases with atypical symptoms. However, potential factors might include a shortage of the preferred treatment, Bicillin L-A, an injectable long-acting form of the antibiotic penicillin. The CDC has advised healthcare providers to prioritize this treatment for pregnant individuals and infants due to its efficacy. The use of alternative antibiotics like doxycycline in men might also contribute to inadequate treatment, as some individuals may not complete the full course of medication.

Understanding the potential implications of this rise in syphilis cases and its manifestation in atypical symptoms is crucial for public health response. The consequences of untreated or inadequately treated syphilis can be severe, leading to long-term complications and potentially fatal outcomes. In light of this, it is imperative to prioritize comprehensive screenings and proper treatment for anyone at risk of syphilis infection.

The implications stretch beyond the scope of this study, intertwining with other emerging healthcare trends and current events. The rise in sexually transmitted infections, including syphilis, highlights the importance of sexual health education and accessible healthcare resources. Furthermore, the increasing prevalence of atypical symptoms challenges healthcare providers to stay vigilant and adapt their screening protocols to ensure early detection and appropriate treatment.

Looking ahead, it is crucial for the industry to address the root causes and tackle the barriers that hinder effective prevention and treatment of syphilis. This includes increased funding for research, education, and awareness campaigns, as well as ensuring the availability of essential medications such as Bicillin L-A. Additionally, partnerships between public health departments, healthcare providers, and community organizations are vital to reaching vulnerable populations and promoting comprehensive sexual health.

As the landscape of infectious diseases continues to evolve, healthcare systems must remain adaptable and responsive to emerging trends. By acknowledging the changing patterns of syphilis infections and implementing proactive measures, we can strive to mitigate the impact of this resurgence and safeguard the well-being of individuals nationwide.

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