2023-11-30 21:02:00
New studies with CART-T and NK cell therapies have shown favorable results in trials conducted so far.
By: Maria Camila Sanchez
November 30, 2023
Due to the autoimmune nature of lupusthe kidneys are one of the main organs affected, causing lupus nephritis, proteinuria, high blood pressure, renal failure, cardiovascular complications, and even leading the patient to need to undergo immunosuppressive treatment.
Lupus nephritis
It constitutes kidney involvement due to Lupus Systemic Erythematosus (SLE) is the most common but serious condition, which manifests itself through the presence of blood or proteins in the urine or deterioration of kidney function, and is estimated to affect up to 60% of patients diagnosed with SLE. affecting men more than women.
This condition still has no cure, but there is treatment, the objective of which is to reduce the symptoms or eliminate them completely and avoid the need to receive dialysis or a kidney transplant.
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CAR-T cell therapy
During exclusive coverage of the annual convention of the American College of Rheumatology, Medicine and Public Health Magazine spoke with rheumatologist Dr. Guillermo Valenzuela who commented that currently various research on cell therapy might provide better results in the treatment of this condition.
“Lupus nephritis is one of the areas where we as rheumatologists have had one of the greatest therapeutic limitations in recent years. Today I am pleased to share new therapeutic advances, and we are talking regarding advances that, I would venture to say, might be a “cure for lupus nephritis”.
According to the specialist, in the study presented at the great event, the exhibitors pointed out a trend towards complete remission of the disease thanks to cell therapy.
“CAR-T, which is a mechanism by which the patient’s T cells are reprogrammed through a laboratory process, currently includes a new molecular engineering and is re-administered to the patient. About this mechanism, which had already been published before and “There have been countless new laboratories looking for the same effect.”
Alternate treatments with favorable results
Likewise, he mentioned that the results of tests with NK cellshave been
favorable by reducing the symptoms associated with lupus nephritis.
“We have also seen that another type of cell that exists, using the NK cells as a vector, they show a great possibility of transforming into a way to reduce B or ‘bad’ cells that lead to the perpetuation of the disease. lupusand especially at the nephritis level,” he pointed out. “It is a reset, that is, we are going to reset the cells so that they do not have that characteristic expression that they have in patients with Lupus“.
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