2024-09-05 14:29:35
September 5, 2024
Psoriasis, a chronic inflammatory skin disease that affects 2 to 3 percent of the world’s population, could soon benefit from a new treatment. A team of researchers from the Cochin Institute has just made a major discovery about the role of a hormone called hepcidin. explain.
Table of Contents
- 0.1 Psoriasis, a chronic inflammatory skin disease that affects 2 to 3 percent of the world’s population, could soon benefit from a new treatment. A team of researchers from the Cochin Institute has just made a major discovery about the role of a hormone called hepcidin. explain.
- 0.2 Treat other illnesses?
- 1 New Insights into Psoriasis: The Role of Hepcidin in Treatment Innovations
Psoriasis is characterized by excessive proliferation of epidermal cells and localized inflammation, manifesting as red patches covered with scales. Although treatments exist to improve patients’ daily lives, the disease remains incurable to date.
A study published in the French Research Journal nature communicationsrevealed the accumulation of iron in the skin of psoriasis patients. Hepcidin, a hormone that regulates iron in the body, is particularly expressed in the skin of patients with severe disease.
As team leader Carole Peyssonnaux explains Iron and immunity From Cochin Research Institute and Director of Research at Inserm,” Hepcidin produced by the epidermis plays a crucial role in iron retention in skin cells. Iron is an essential metal for cell proliferation, and this retention promotes cell division and aids in the recruitment of neutrophils. Characteristics of psoriatic lesions.
Treat other illnesses?
Scientists then developed mouse models (animal testing models) to study the effects of hepcidin more precisely. The results showed that activation of the hepcidin gene induces features of psoriasis, while inactivation causes the loss of these features.
Based on these results, the team is now working on developing new drugs that can neutralize hepcidin. These treatments can be used as maintenance therapy after an attack or to prevent recurrence of the disease during the remission phase.
Things to note : The researchers hope to apply this finding to other inflammatory skin diseases. Additional research is ongoing to explore these possibilities.
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New Insights into Psoriasis: The Role of Hepcidin in Treatment Innovations
Understanding Psoriasis
Psoriasis is a chronic inflammatory skin disease that affects approximately 2 to 3 percent of the global population. This condition is characterized by the excessive proliferation of epidermal cells and localized inflammation, leading to red, scaly patches on the skin. Despite the availability of various treatments aimed at alleviating symptoms, psoriasis remains incurable, posing significant challenges for patients in managing their condition.
Groundbreaking Research on Hepcidin
Recent research published in the reputable French journal Nature Communications has shed new light on the relationship between psoriasis and iron accumulation in the skin. A team of researchers from the Cochin Institute made a significant discovery about the hormone hepcidin, known for its regulatory role in iron metabolism within the body.
According to Carole Peyssonnaux, team leader at the Cochin Research Institute and Director of Research at INSERM, ”Hepcidin produced by the epidermis plays a crucial role in iron retention in skin cells. Iron is an essential metal for cell proliferation, and this retention promotes cell division and aids in the recruitment of neutrophils, which are characteristic of psoriatic lesions.”
The Impact of Hepcidin on Psoriasis
Hepcidin is primarily known for its involvement in controlling iron levels in the bloodstream, but its significance in skin health is increasingly recognized. The study highlights that increased expression of hepcidin in the skin of individuals with severe psoriasis correlates with excess iron accumulation. This finding suggests a potential mechanism by which psoriasis may exacerbate, driven by inflammation and metal ion dysregulation.
Key Findings:
- Iron Accumulation: Patients with severe psoriasis demonstrated significant iron accumulation in their skin.
- Cell Proliferation: Enhanced hepcidin levels lead to iron retention, fostering the proliferation of epidermal cells and recruiting immune cells (neutrophils), contributing to psoriatic lesions.
- Potential Treatment Target: The findings propose hepcidin as a potential target for new psoriasis treatments, offering hope for improved management strategies.
Potential for Treating Other Conditions
The research extends beyond psoriasis, opening avenues for exploring hepcidin’s role in other diseases characterized by chronic inflammation and iron dysregulation. Scientists at Cochin Institute are investigating mouse models to better understand hepcidin’s effects and explore its implications in the treatment of various conditions.
Future Directions in Psoriasis Treatment:
The identification of hepcidin as a crucial factor in psoriasis pathology may pave the way for innovative treatments. Future therapies could aim to modulate hepcidin levels or address iron dysregulation in the skin, offering new hope to individuals struggling with this challenging condition.
Conclusion
The recent study on psoriasis and hepcidin represents a significant advancement in understanding the disease’s underlying mechanisms. This groundbreaking research illuminates the path toward novel treatment options for psoriasis by targeting hepcidin and addressing iron dysregulation. As scientists continue to explore hepcidin’s role in skin health and disease, patients may soon benefit from innovative therapies that enhance their quality of life and address the root causes of their condition.
By enhancing the visibility of this crucial research and its potential implications, this article aims to provide essential insights into the ongoing efforts to discover more effective treatments for psoriasis. Stay tuned for further developments in this exciting field of study, as we move closer to a future where psoriasis management can be greatly improved.
