2023-08-12 06:01:57
Bacteria can detect colon cancer cells
Enter 2023.08.12 15:00 Hits 3,200 Enter 2023.08.12 15:00 Edit 2023.08.12 12:28 Hits 3,200
Drinking yogurt seems to be able to replace a colonoscopy. [사진=게티이미지뱅크]Colonoscopy is the test that you want to avoid the most in a health checkup.
However, it is the most effective way to detect colorectal cancer early, so it is an essential screening item that cannot be avoided.
However, in the future, it seems that drinking yogurt can replace colonoscopy. This is because engineered microorganisms can find hidden cancers in the body.
According to a study published in “Science”, a journal published by the American Association for the Advancement of Science, researchers at the University of California, USA, showed that colon cancer cells can be found with bacteria through an experiment on mice.
Because tumors spread or shed DNA into the environment, this DNA can be analyzed in the laboratory. But it is undetectable where the DNA is released
To this end, the researchers used Acinetobacter baylyi, a thief bacterium known for its ability to gather DNA from its environment.
Using its foraging abilities (called natural abilities), Acinetobacter Bailey causes its genome to coalesce chunks of DNA that can provide new genetic recipes for convenient proteins.
The researchers designed Acinetobacter Bailey to detect fragments of DNA shed from colon cancer cells grown in the lab and from mice bearing colon tumors.
When Acinetobacter Bailey discovered tumor DNA, he integrated the material into his genome to activate antibiotic resistance genes.
When this gene is activated, Acinetobacter Bailey, which is extracted from feces of a human host, grows on an agar culture dish containing antibiotics, which signals that cancer cells have been discovered.
“When we saw the bacteria that took up the tumor DNA under the microscope, we were really surprised,” said the research team.
The biosensor the researchers created is designed to detect a specific KRAS mutation found in regarding 40% of colorectal cancers, a third of lung cancers, and most of pancreatic cancers.
However, in order to use Acinetobacter Bailey in humans, it must first be verified that it can be safely delivered by mouth and stably detect cancer cells in stool samples.
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