2023-10-11 20:29:16
This bioprinted skin, which includes several types of cells, promotes skin regeneration, vascularization, healthy remodeling of the extracellular matrix and the formation of epidermal ridges in wounds, which also accelerates their healing. Lead author Dr. Anthony Atala, director of WFIRM, sees this as “a note of optimism for wound healing.”
Hope for healing burns
Skin regeneration has long been studied in the hope of offering burn victims, wounded soldiers or patients suffering from certain skin disorders, an opportunity for complete healing. The grafts available are often temporary and if permanent, only include certain elements of normal skin. The final appearance is often “scarred”.
Creating full thickness skin has not been possible until now.
The study leads to the development of a technique for bioprinting full-thickness skin, comprising the 6 main types of primary human cells present in the skin, combined with specialized hydrogels as bio-ink. A full-thickness, multi-layered skin is thus created, containing the 3 layers present in normal human tissues: the epidermis, dermis and hypodermis. Once transplanted under preclinical conditions,
bioprinted skin welcomes the formation of blood vessels and usual skin patterns and the tissues heal normally. Bioprinted skin allows for better wound closure, skin contraction is reduced and collagen production is increased, which reduces scarring.
“Complete skin healing is a significant clinical challenge, affecting millions of people worldwide, with limited options. These results show that creating full-thickness bioengineered human skin is possible and promotes faster healing and a more natural appearance.”
Fully functional skin regeneration is now possible.
Bioengineered skin grafts will very soon cover the entire depth of the wound.
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