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Retinoids: watch out for your bones
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Several cases of hyperostosis have been reported in children and young adults who have taken isotretinoin.
THE topical retinoids – by the cutaneous route: in gel, cream or other galenics – are very widely used in the treatment of dermatoses such as acne and psoriasis. Review Prescribe teaches us that taking retinoids derived from vitamin A, theisotretinoin (Procuta or others), already contraindicated in pregnant women or considering pregnancy because of the risk of malformation of the fetus (teratogenic risks), also exposes (and among others), in the context of severe acne, to hyperostosis, tendon or ligament calcifications or premature cartilage welding of conjugation.
Several cases of hyperostosis have been reported in children and young adults who have taken isotretinoin orally for several months. Patients described the following symptoms: morning stiffness, neck pain, chest or lumbar pain, pain at the insertion area of the Achilles tendon, etc.
Prescrire reminds that cases of hyperostosis – which are characterized by excessive production of calcifications or bone tissue – are also to be deplored with the taking of other retinoids such as acitretin (Soriatane), alitretinoin (Toctino or other), used orally, and the tretinoin (Vesanoid).
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