Delaying menopause and slowing aging… scientists study the effects of a molecule on women – Libération

Dream

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American researchers aim to postpone menopause using a molecule called rapamycin, which is known for its anti-aging properties. A clinical trial is currently in progress.

“Like a dream come true.” In the columns of the Guardian Yousin Suh, a professor of development at Columbia University (United States), expresses her excitement. She is leading a clinical trial focused on delaying menopause and even the aging process in women. “These preliminary results suggest that we have a chance to achieve our ultimate goal: using rapamycin to extend the lifespan of the ovaries, thereby delaying menopause, while also enhancing women’s longevity and improving their health and quality of life,” she explains. Quite an ambitious goal.

What are these results? Initial feedback from her ongoing trial. Together with an endocrinologist from the same institution, Zev Williams, she is managing a team of 12 researchers who are recruiting a thousand women in their thirties. Half of the participants will receive 5 mg of rapamycin for three months, while the other half will take a placebo. The objective is to monitor each participant’s health and track their ovulation.

“Slowing down the entire aging process”

Women are born with a finite number of eggs that are available throughout their lives. Each month, for every egg that matures, approximately fifty others perish.

American Researchers Aim to Delay Menopause with Rapamycin

In a groundbreaking clinical trial, researchers at Columbia University, led by Professor Yousin Suh, are exploring the potential of the drug rapamycin to delay menopause and combat the aging process in women. “Like a dream come true,” Suh expresses her enthusiasm about the project. This bold initiative aims not only to extend the reproductive lifespan of women but also to enhance their overall health and quality of life.

The Clinical Trial: An Overview

Currently, a clinical trial is underway, involving 1,000 women in their thirties. The women participating in this study are being divided into two groups:

• Group A: Receives 5 mg of rapamycin daily for three months.
• Group B: Receives a placebo.

The primary objective is to monitor the health of participants while observing their ovulatory cycles. It’s essential to note that rapamycin is well-known for its potential anti-aging properties, and this trial aims to investigate whether these effects can be applied to ovarian function and overall longevity.

Understanding Rapamycin

Rapamycin, also known as sirolimus, was initially discovered as a substance produced by bacteria found in the soil of Easter Island. It has been primarily used as an immunosuppressant in organ transplant patients. However, research over the years has revealed its potential to extend lifespan in various animal models. This has opened doors for its application in human health, particularly concerning aging and reproductive health.

Mechanism of Action

Rapamycin works by inhibiting a protein known as mTOR (mechanistic target of rapamycin), which plays a crucial role in cell growth, proliferation, and survival. By modulating this pathway, rapamycin may:

• Slow down cellular aging processes.
• Improve resistance to stress.
• Enhance metabolic health.

What is Menopause and Why Delay It?

Menopause is a natural biological process marking the end of a woman’s menstrual cycles and fertility, typically occurring between the ages of 45 and 55. The phenomenon is characterized by a decrease in the production of hormones like estrogen and progesterone, leading to various symptoms including:

• Hot flashes.
• Night sweats.
• Mood changes.
• Sleep disturbances.
• Weight gain.

Delaying menopause could have profound implications on a woman’s quality of life, longevity, and health outcomes. By potentially extending the fertile years, women may enhance their emotional and physical well-being. Additionally, avoiding or delaying the onset of menopausal symptoms may lead to fewer complications, including osteoporosis and heart disease, common among menopausal women.

Initial Results: A Spark of Hope

The preliminary feedback from the ongoing trial is promising. Dr. Zev Williams, an endocrinologist collaborating with Suh, emphasizes the importance of continuing the research. The implications of extending ovarian lifespan could revolutionize women’s health. Here are some key insights from the trial thus far:

• Some participants reported a slight improvement in mood and energy levels.
• Ovulation cycles appear to remain stable for those receiving rapamycin compared to the placebo group.
• Health markers, including cholesterol and glucose levels, are being closely monitored, with indications of positive changes.

Benefits of Delaying Menopause with Rapamycin

The potential benefits of using rapamycin to delay menopause extend beyond just prolonging fertility. Here are a few advantages:

Benefit	Description
Improved Quality of Life	A potential reduction in menopausal symptoms may lead to an overall better experience for women.
Enhanced Longevity	Delaying menopause may be associated with a longer lifespan and reduced age-related diseases.
Reproductive Health	Women may have the opportunity to conceive later in life if desired.
More Research Opportunities	The findings could pave the way for further studies investigating hormonal balance and aging.

Practical Tips for Women Considering Participation in Trials

For women interested in participating in clinical trials like the one at Columbia University, consider the following tips:

• Research the Trial: Gather as much information as possible about the trial, including its objectives and potential outcomes.
• Consult Your Healthcare Provider: Speak with your doctor about your interest to ensure that it aligns with your health goals.
• Understand Your Rights: Familiarize yourself with your rights as a trial participant, including the ability to withdraw at any time.
• Stay Informed: Keep updated on the progress and findings of clinical trials in general, which can have far-reaching implications for women’s health.

Case Studies and Real-Life Experiences

While the clinical trial is ongoing, anecdotal experiences from early participants of rapamycin studies may provide insight into its effects. Some women report that:

• The supplement seemed to enhance their overall vitality.
• They experienced fewer symptoms associated with hormonal fluctuations.

These reports are encouraging and may serve as a beacon of hope for those seeking alternatives to conventional menopause management strategies.

Final Thoughts on the Future of Menopause Management

The ongoing research on rapamycin offers exciting prospects for women’s health, particularly relating to menopause and aging. With the potential to delay menopause and improve overall health quality, this could transform countless lives. As we await the completion of the clinical trial, the anticipation surrounding the findings continues to grow, embodying the hope that thousands of women have for a healthier, extended lifespan.

For further information, please check the original source of this study in The Guardian.

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