Research hyperlinks saturated fat to Alzheimer’s

BARCELONA (EFE).— A analysis led by the Rovira Virgili College (URV), in Spainfound the mechanism that hyperlinks a weight loss plan wealthy in saturated fat to Alzheimer’s, a revelation that permits us to outline the hyperlink between this illness with weight problems and kind 2 diabetes.

It is a assertion, The URV defined that the examine, revealed within the journal “Vitamins”targeted on seeing how a high-fat weight loss plan impacts molecules within the blood and different tissues, such because the mind, that act as markers and regulators of the illness.

To realize this, they examined the adjustments in microARNs —small molecules of ARN important in genetic regulation—associated to insulin in a mouse mannequin predisposed to develop Alzheimer’s in maturity and who adopted a weight loss plan excessive in fats, particularly a saturated kind.

The outcomes present that metabolism worsened after following this weight loss plan for six months, with a major improve in physique weight and a worse response to glucose and insulin, that are traits much like these of weight problems and kind 2 diabetes in ladies. individuals, in line with the examine.

Monica Bullóprofessor of Division of Biochemistry and Biotechnology of the Rovira Virgili College and researcher of the examine, identified that “the outcomes obtained symbolize an advance within the data of the mechanism that will clarify the connection between weight problems, kind 2 diabetes and the event of Alzheimer’sand supply new targets for the potential prevention and remedy of the illness.”

In response to URV, There have been already research that confirmed that, after following a high-fat weight loss plan, mice developed Alzheimer’s lengthy earlier than those that had a standard weight loss plan, however till now the mechanisms that triggered the development of the illness had been unknown.

The researchers highlighted that the report “opens the door for future analysis on meals methods as a potential strategy to deal with Alzheimer’s.”

It additionally “underlines the significance of a balanced weight loss plan for the prevention of neurodegenerative ailments and highlights the potential of microARN as targets for therapeutic interventions,” they added.

The analysis additionally highlights an alteration of a number of microRNAs associated to processes that may harm the mind, reminiscent of the buildup of β-amyloid plaques (protein clumps that type within the mind and function markers for Alzheimer’s); the manufacturing extreme tau protein (which, if uncontrolled, can harm mind cells), and irritation throughout the mindwhich can also be linked to this illness.