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Mr. Joe Biden, President of the United States Detected Covid-19 Repeated within 4 days after a negative test result. As a result, the issue of recurrence after receiving antiretroviral drugs or medically known as “Covid-19 rebound”, especially among patients who received antiviral drugs Paxlovid (Paxlovid) by Fire Company. Sir, back in the spotlight again.
Medical and public health experts have been collecting statistics and studying the repeated outbreaks of COVID-19. Among patients who have been taking Pfizer’s antiviral drug Paxlovid for some time But no definitive cause or link to this drug has been established.
While the US Centers for Disease Control confirmed that This antiviral drug is effective in treating and it is still recommended that patients take it as soon as possible after symptoms develop. but warned that COVID-19 patients who received the full course of Paxlovid and had a negative test result. There is a chance that the virus will be re-detected and re-infected. But most will have mild illness.
What happened to Biden?
President Biden, 79, tested positive for the coronavirus on July 21. He had completed a five-day course of the antiviral drug Paxlovide until the virus was not detected on July 26. . And three more tests after that, no more infections found. As a result, Mr Biden ended his quarantine and resumed his duties.
Politico news website, the famous US political media reported that after not detecting the virus. Mr Biden has appeared in public without a mask. This is contrary to the recommendations of the US Centers for Disease Control. indicating that a person infected with COVID-19 Must wear a mask for at least 10 days since the infection is detected.
Late last Saturday (July 30), Biden tested again for coronavirus. White House physician Kevin O’Connor said Biden was one of a minority of coronavirus patients treated with the antiviral drug Paxlov and later tested positive. Repeat after recovering from illness (Covid-19 rebound)
Dr. O’Connor added that Mr Biden currently has a mild illness. and does not require additional antiretroviral therapy. But he will continue to be in quarantine at the White House and under close medical supervision.
while Mr Biden who had to cancel the trip to meet his wife at home in Delaware tweeted that Covid-19 test results His back was positive again. “This is what happened to a small number of people. I have no symptoms But must continue to detain for the safety of those around them. I still work every day and will be back to see everyone soon.”
Know Pax Lowid
Paxlovid, published on the website of the Food and Drug Administration (FDA), which approves Pfizer’s importation of Paxlovid for emergency use states: Paxlovid is an antiviral drug used to treat COVID-19. in patients aged 18 years and over who do not require supplemental oxygen and are at high risk of spreading to COVID-19 with severe symptoms
“Paxlovid inhibits viral proliferation in cells and this inhibition stops viral proliferation in the body. This helps your body fight viral infections. And it may help you get better faster.”
Paxlovid contains two medicines, nermatrelvir and ritonavir. The recommended dose is 2 nermatrelvir tablets plus 1 ritonavir tablet: Take all 3 tablets at the same time twice daily (morning and night) for 5 days. Currently, a number of countries have registered Paxlovid for the treatment of COVID-19 patients, including the United States, United Kingdom, Canada, Singapore and China, among others.
For Thailand, after the FDA approved it to be imported for use in an emergency The Cabinet also approved and approved the budget for the Ministry of Public Health to purchase 50,000 treatment courses of Paxlovid or for 50,000 patients, after which the Medical Department signed a contract to purchase the drug from Pfizer on March 24. and received the medicine on April 11
image source, Facebook/Department of Medicine
The Department of Medicine examined Paxlovid for 50,000 treatment courses from Pfizer (Thailand) Co., Ltd. on April 11, 2022.
Pax Lovid with “Covid Rebound”
During July 2022, at least two Thai doctors were Dr. Teerawat Hemajuta, director of the Center for Emerging Health Sciences. Faculty of Medicine Chulalongkorn University and Dr. Manoon Leechawengwong, a specialist in respiratory diseases Wichaiyut Hospital has released information about the recurrence of the coronavirus disease 2019 in patients who have completed the course of antiretroviral therapy and have recovered.
Dr. Teerawat posted a message on his personal Facebook page on July 22, citing reports from the United States. analyzing data on COVID-19 cases Between January 1 and June 8, 2022, 11,270 patients were treated with Paxlovid and 2,374 were treated with molnupiravir within the period. 5 days after infection It was found that the patients were re-tested after cured or rebounded, with both groups asymptomatic. The group with symptoms of fever, chills, sore throat, loss of taste and smell. and groups requiring hospitalization
Dr. Thirawat stated that Recurrent infections or relapses in people taking paxlovid and molnupiravir “No difference,” but people with underlying diseases are more likely to experience recurrent eruptions.
image source, Archyde.com
Paxlovid contains two medicines, nermatrelvir and ritonavir. The recommended dose is 2 nermatrelvir tablets plus 1 ritonavir tablet: Take all 3 tablets at the same time, twice daily (morning and night) for 5 days.
“There is no difference in the risks between the two drugs. But it depends on the condition or congenital disease of the infected person, having heart disease, high blood pressure, cancer, paralysis, lung disease, kidney disease, liver disease, obesity, diabetes, immune system diseases. undergoing an organ transplant including the administration of immunosuppressive drugs And it has nothing to do with getting vaccinated or not.”
“The mechanism of the recurrence is unknown. But it may be related to the treatment unable to completely eliminate the virus. or a drug-resistant virus?” Dr. Teerawat stated.
Dr. Manoon gave information via Facebook at the same time that It was reported that patients with COVID-19 Patients who were treated with antiretroviral paxlovide or molnupiravir for 5 days feel better and may have a negative test result, such as ATK, but 2-8 days after discontinuation. drug Came back with a new illness like the first time And the ATK test result turned out to be positive again, known as Covid-19 rebound.
“This phenomenon is rare, only 1-2% after returning to illness. No need to take new antiviral drugs again. However, quarantine for at least 5 days from the onset of the second round of illnesses is requested. and wear a mask for another 5 days until 10 days are complete.”
Dr. Manoon also stated that “When most Thai people have access to molnupiravir We will see more of the Covid-19 rebound after taking molnupiravir,” he said, adding, for example, a 60-year-old woman who received molnupiravir for five days. The ATK test was negative, but 7 days later came back sore throat, hoarseness, and the ATK test came back positive. which is expected to be a Covid-19 rebound from the drug molnupiravir
Dr. Manoon stressed that relapsed patients do not need to take antiretroviral drugs again. to take medication according to symptoms After that it will disappear on its own.
US Centers for Disease Control how do you recommend
May 24, US Centers for Disease Control has issued a recommendation on the re-emergence of the virus in COVID-19 patients treated with paxlovid by confirming that Paxlovid is still the antiviral drug that patients with COVID-19 with mild to moderate symptoms which is at risk of having severe symptoms Should be given immediately after symptoms of illness. This is because it is effective in preventing worsening symptoms and reducing the risk of death.
Reappearance of the virus or recurrence of illness usually occurs 2-8 days after the patient’s symptoms improve. This new cycle of illness is usually mild. and do not need to receive another antiviral drug Center for Disease Control Recommends Covid-19 rebound patients to quarantine and wear masks for at least 10 more days.
“If you are diagnosed with COVID-19 and has recovered in the past 2 weeks. You have a chance of detecting the virus or coming back. If the test result is positive again You will need to self-isolate for another 5 days, after which symptoms improve and you have not had a fever for 24 hours, even if you haven’t taken fever-reducing medication. So you can return to your normal life.”
In addition, the Center for Control has also asked patients who have returned to illness or have recurrent infections after receiving treatment with Paxlovid to contact for information. Pfizer for the benefit of further research studies