Rama Hospital Genome Center has detected two ‘Omicron’ subspecies BA.2 in Thailand, indicating that it is contagious and spread faster than the main strain, with 10,811 cases worldwide.
Date 25 Jan. 65 Medical Genome Center Faculty of Medicine Ramathibodi Hospital Mahidol University Post pictures and messages via Facebook page. ‘Center for Medical Genomics’ that Omicron Main Species “BA.1” and Subspecies “BA.2 and BA.3” in Thailand Revised 25/1/2522 at 14.00
The nature of the 2019 coronavirus, when a primary species emerges, is followed by mutation into a subspecies. In the case of Omikron, the primary variant is “B.1.1.529” or “BA.1” and then two more subspecies mutate “BA.2” and “BA.3”.
Main species of omicron “BA.1” The whole genome has been genetically decoded from a total of 514,417 global cases (8%), found in Thailand, 561 (23%) with approximately 60-70 different mutations from the original Wuhan strain (from G. All gnomes, 30,000 positions)
Omicron subspecies BA.2 A total of 10,811 (<0.5%) cases have been genetically decoded worldwide, 2 (1%) were found in Thailand, with approximately 70-80 mutations from the original Wuhan strain. position
way Medical Genome Center, Ramathibodi Hospital One sample of BA.2 was detected using “Mass array genotyping” technology, which is being confirmed with a “long read, whole genome sequencing” technique. The completion is expected this week.
The infected person had no severe symptoms. The X-ray results showed mild pneumonia. The doctor gave me favipiravir. (Favipiravir) has gone and is now recovering. No virus detected from swap samples.
Omicron subspecies BA.3 Whole genome decoded from approximately 86 global samples (<0.5%) Not detected in Thailand (not detected) Mutated 55-65 locations different from the original Wuhan strain.
Initial laboratory screening to separate the “delta” and “omicron” strains is usually performed by RT-PCR 3 sites on 3 genes.
Delta was detected with all three RT-PCR genes, while the primary omicron strain “BA.1” was detected with only two of the three RT-PCR genes because it did not detect the S gene or had “S target failure (SGTF). )” due to the mutation resulting in the absence of amino acid site 69-70 (del 69-70) on the spiny protein until the PCR primers were unable to detect the S gene.
BA.2 is sometimes referred to as the Stealth Variant” because it can test all three RT-PCR genes. This makes it indistinguishable between “Delta” and “BA.2” because delta can detect RT-PCR in all three genes as well.
The UK Health Security Agency (UKHSA) declared BA.2 a Variant Under Investigation (VUI) on 21 Jan.
at the Medical Genome Center Due to the use of “genotype” technology, “S target failure (SGTF)” problems are not encountered. Both BA.1, BA.2, and BA.3 and Delta alpha beta gamma detection kits can be developed simultaneously in Single tube reaction within 24-48 hours at a cost more economical than whole genome transcription.
BA.2 mutated differently from the original “Wuhan” strain. Approximately 70-80 locations, however, there is no clinically conclusive data on whether the symptoms are more severe than the main omicron strain BA.1 or not.It is estimated from epidemiological data that it may spread somewhat faster than omicron BA.1.
BA.2 has been in the interest of scientists around the world for a while. before losing interest because there is a limited outbreak
But now it is found that the outbreak has spread more The researchers were able to decode the entire genome from 10,811 samples from around the world.
Globally, only 86 samples of the entire genome were decoded for BA.3, with approximately 55-65 different mutations from the original Wuhan strain. There is not much clinical data available.
