2024-08-17 06:00:05
Could the idea of giving the human body regenerative abilities, like those of superheroes, become a reality? A Japanese study explores this bold avenue by transferring regenerative genes to fruit flies, revealing promising prospects for the medicine anti-aging.
Researchers at the University of Tokyo have introduced regenerative genes from simple organisms into fruit flies, a more complex animal. This manipulation has been shown to suppress age-related intestinal problems in the flies. The discovery paves the way for further studies of genes from highly regenerative species to rejuvenate stem cells and extend healthy lifespans. health organizations.
Professor Yuichiro Nakajima and his team targeted genes specific to highly regenerative species, the high regeneration JmjC (HRJD) genes, and transferred them into Drosophila melanogasterTheir goal was to examine the effects of these genes on regeneration and aging fruit flies.
Although the engineered flies did not regenerate injured tissue, Nagai observed an increase in intestinal stem cell division and a suppression of poorly differentiated cells in old flies, which had a noticeable effect on their longevity.
The two images on the left show intestinal proteins disrupted by aging, while those on the right show the same proteins better preserved thanks to HRJD genes.
Credit: ©2024 Hiroki Nagai CC-BY-ND
The experiments were lengthy, as the aging process in flies takes about two months. Despite the difficulties, the results obtained open up prospects for new anti-aging strategies and stem cell-based therapies in humans.
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