Protein Discovery: Castration Resistance in Prostate Cancer

2023-06-15 23:38:00

A protein associated with castration resistance was discovered.

Prostate cancer is the second most common cause of death among men, and a protein associated with castration resistance is found, which allows tumors to grow even when testosterone levels are very low.

Patients with locally advanced prostate cancer or metastatic prostate cancer are treated with androgen deprivation therapy as the first-line treatment, and most of the prostate cancer patients who have undergone androgen deprivation therapy show castration resistance, in which tumors grow even when testosterone levels are very low, and Prof. Ping Yi When the researchers reduced testosterone levels to castration levels, they found that prostate cancer cells were converted into castration-resistant cells by a protein called TRAF4.

Overexpression of RAF4 not only transforms prostate cancer cells into castration-resistant cells, but can also spread the cancer to other parts of the body, and androgen-unresponsive cancer cells have higher levels of TRAF4 than androgen-responsive cancer cells.

University of Houston

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