[베리타스알파=이정원 기자] According to a survey by KB Financial Group in 2021, as of the end of 2020, there are 6.04 million households with companion animals nationwide, accounting for 29.7%, and the number of companions is 14.48 million, with more than 1 out of 4 being companions, and ‘dog households’ accounting for 80.7%. It is said. The main advantage that companion animals give to people is companionship and emotional support. Dogs are social animals and provide unconditional love and emotional support to their owners, making them excellent companions for people living alone and families with children. As for health benefits, research has shown that owning a dog can have a positive impact on a person’s physical and mental health, for example dog owners tend to be more physically active and have lower blood pressure and cholesterol levels, and petting a dog is It has been shown to reduce stress and anxiety. Caring for a dog requires responsibility and discipline, which can be a great way to teach children important life skills. This includes feeding, grooming, exercising, caring for and cleaning the dog. Owning a dog can also improve socialization for both children and adults. For example, walking your dog can give you a chance to meet and interact with other dog owners in the neighborhood. Dogs can also provide their owners with a sense of safety and security. They may bark to warn owners of potential danger or intruders, and their presence alone can deter intruders. In summary, owning a dog offers many benefits to families, including companionship/emotional support/health benefits/responsibility/increased socialization/enhanced safety and security. However, it is important to remember that owning a dog is also a great responsibility and requires providing proper care and attention to the animal. Therefore, this study began with the idea that the health promotion of companion dogs, which greatly helps people’s welfare, can greatly help people’s health improvement.
Among canine diseases, the fatality rate is high and there is no special treatment for diseases caused by parvovirus. Canine parvovirus is a virus that causes a contagious viral disease in dogs. Parvovirus is highly contagious from dog to dog through feces and saliva. Canine parvovirus attacks the dog’s intestines and immune system, causing severe vomiting/diarrhea and dehydration. CPV can be transmitted through direct contact with infected dogs or feces, as well as indirect contact with contaminated objects or the environment. In other words, the main problems in CPV-infected dogs are severe dehydration, electrolyte imbalance, and secondary bacterial infections. Puppies and young dogs are particularly vulnerable to the virus and can develop life-threatening complications such as sepsis/myocarditis/encephalitis. Currently, there is no specific treatment for CPV, and the main focus of treatment is supportive care to manage symptoms and prevent complications. These typically include hospitalization/intravenous fluids/electrolyte replacement/anti-nausea drugs and antibiotics to prevent or treat secondary bacterial infections. Vaccination is the most effective way to prevent CPV infection, but it is not 100% effective and breakthrough infections can still occur. Some dogs may have an inadequate immune response to vaccination and may still be infected. The vaccine administration method has limitations because it requires multiple administrations and additional vaccinations, and in some cases may not provide long-lasting immunity, which can be a great financial burden for families raising dogs.
Canine parvovirus type 2 is a virus that causes intestinal hemorrhage and bloody stool. It began to occur in livestock and wild canines in 1978 and is widespread worldwide, and is still reported in many countries as a pathogen that continues to mutate. The virus is highly contagious, with an incidence of 33-84% in unvaccinated dogs and 15-48% in vaccinated dogs, with a mortality rate of 10% in adult dogs and 91% in puppies. The disease can affect dogs of any age, but severe infections are most common in puppies between the ages of 6 weeks and 6 months. As soon as they are born, young puppies acquire immunity from the mother dog’s colostrum, and the puppies absorb the antibodies produced by the mother into the blood through the intestines. When maternal antibodies are present in high proportions in puppies, maternal antibodies neutralize the vaccine and the actual effective amount of vaccine that can cause acquired immunity to be experienced is small.
In this study, we aimed to develop a material that inhibits the activity of viral enzymes related to viral replication as a new alternative to supplement vaccines developed with amino acids constituting VP2, a major structural protein of capsid, a molecule that causes viral mutations. it started. This is a method used in the development of materials for inhibiting the replication of the Covid-19 virus in our laboratory. In this study, we extensively screened components of natural products that inhibit the endonuclease activity of the N-terminal of NS1, a non-structural protein applicable to all regardless of viral mutations, and inhibited the action of this replication-related essential enzyme to CPV-2. The purpose of this study is to identify the mechanism that inhibits the replication of the virus to prevent viral diseases.
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