The sequence of works “From surgical procedure to genome, transcriptome, metabolome: basic and utilized analysis and improvements (2008-2022)” was ready by the pinnacle of the Gastroenterology, Nephrourology and Surgical procedure Clinic, academician prof. Prof. Kęstutis Strupas, director of the Institute of Scientific Medication and head of the Stomach and Oncosurgery Middle of Santaras Clinics. Dr. Tomas Poškus and head of the Translational Analysis Middle for Visceral Medication and head of the Organ Transplantation and Coordination Middle of Santaras Clinics. Aistė Kielaitė-Gulla. Academician prof. Kęstutis Strupas agreed to inform in regards to the cycle of scientific works submitted for the prize.
Implementation of transplantology in Lithuania
In response to prof. Kęstutis Strupa, the very title of the challenge reveals that science in medication is altering very strongly. “If prior to now a surgeon, primarily based on his medical apply, that’s, evaluating experiences, and so forth., ready scientific stories, at the moment such medical research alone should not sufficient. In response to the scientific rating, such articles at the moment are rated now not Q1 or Q2, however Q3-This autumn,” mentioned the academician.
It’s fascinating that This autumn articles are now not thought of scientific manufacturing in some universities. The professor informed how in 2009 The congress of the German Society of Surgeons turned the impetus to maneuver in the direction of primary sciences: “Since 1990 I’m a member of the German Society of Surgeons. I take part yearly. I used to be stunned in 2009. Two German surgeons who labored on the Karolinska Institute in Stockholm have been awarded prizes on the Congress of German Surgeons.
Certainly one of them was awarded the prize for genetic analysis in surgical procedure, the opposite for the invention of the metabolome in one of many inflammatory surgical processes in acute pancreatitis. After coming back from the conference, I made a presentation and informed my colleagues: the world is altering, our medical research are fascinating, however at the moment there’s a must delve into genomics, proteomics, metabolomics, DNA, RNA and different basic areas of drugs.”
The primary a part of the cycle of scientific works – improvements in minimally invasive surgical procedure and transplantology Since 2002, after changing into the pinnacle of the Stomach Surgical procedure Middle at VU Santaras Clinics, now we have carried out many new MIC methodologies within the remedy of varied illnesses with our colleagues. Transplantology was an distinctive discipline on the time once we began from scratch. “Lithuania is a frontrunner within the discipline of transplantology within the Baltic international locations. Now we have carried out 150 liver, 20 pancreas and kidney complicated, in addition to many implementation of synthetic liver perfusion, pancreas cell transplants. All that is the results of one course of our clinic colleagues.
I keep in mind, we had already completed 50 liver transplants, and in 2014, inspired by the previous dean of the College of Medication, Zita Aušrelė Kučinskienė, I wrote a monograph “Liver Transplantation” for submission to the Lithuanian Science Prize”, mentioned the academician. Nevertheless, the prize that point was awarded to a different scientist’s work on genetics. “My colleagues and I got interested on this course, we began implementing it. My very own work started to separate into a number of areas. Behind all that is the concept that stomach surgical procedure is a fancy discipline. The considering of my era was as follows: you might be an stomach surgeon, so you’ll be able to function on all the things,” mentioned the professor.
At present, in keeping with the academician, there are specialised surgical procedures: transplantology, coloproctology, hepatopancreatic system, digestive tract surgical procedure, endocrine and metabolic surgical procedure, and so forth. Subsequently, the second a part of the work cycle – prof. Tomas Poškaus on coloproctology – was supposed to point out that stomach surgical procedure actually consists of directional sections,” mentioned the professor.
Coloproctology, visceral medication and cooperation with international international locations
in 2009 prof. Kęstutis Strupas along with prof. Tomas Poškumi carried out the colon most cancers screening program in Lithuania. “The ministry shaped a gaggle that I headed. That program is at present below profitable improvement. In response to outcomes and reliability, it is without doubt one of the best-rated applications not solely in Lithuania, but additionally in Jap European international locations.
Prof. Tomas Poškus is the vice-chairman of the European Society of Coloproctology, a member of the board of the European Affiliation of Surgeons, and I feel he is without doubt one of the finest coloproctology surgeons within the Baltic States. The medical apply research he’s growing are built-in into the final research of European coloproctologists,” mentioned the professor about his colleague’s contribution to the preparation of the cycle of awarded scientific works. The third a part of the work cycle, he mentioned, is meant to point out that surgical procedure with out a scientific sub-center is unviable at the moment.
“Sure, in 2015/2016 Dr. joined the scientific analysis. Aistė Kielaitė-Gulla. A researcher within the historical past of training – research at each Harvard and Stanford, she has spent a variety of time in america, and her final internship was Memorial Sloan Kettering Most cancers Middle, which is at present a world “forge” for most cancers, oncology and primary analysis. in 2019 The Middle for Translational Analysis in Visceral Medication was established on the College of Medication to develop translational analysis, or in different phrases, “from the scientific laboratory to the working room/bedside”. The middle is split in keeping with the aforementioned scientific analysis teams, and younger folks work in them. Presently, Dr. AKGulla is the pinnacle of this heart,” mentioned prof. Ok.Strup.
The complete cycle consists of medical, basic and translational analysis, which analyzes intimately the organic mechanisms of illnesses of the digestive tract, the pathogenesis of illnesses, which helps to grasp the illness on the degree of a single cell, and the outcomes of all scientific discoveries are utilized in surgical apply. Analysis has been carried out with one of the best universities in Europe: Heidelberg and Hamburg (Germany), Leuven (Belgium), Lund (Sweden), Padova (Italy), Oslo (Norway), VU Life Sciences Middle (GMC) and others. “In 2002, after I turned the pinnacle of the Stomach Surgical procedure Middle of Santara Clinics, my colleague Prof. Markus W. Büchler turned the pinnacle of the Surgical procedure Middle of the College of Heidelberg.
Prof. Büchler is a world-renowned pancreatic and hepatopancreatic surgeon. Yearly, a number of younger surgeons from our heart traveled to Heidelberg College for internships and analysis. Later, we additionally began collaborating with scientists from the College of Graz in Austria – there’s a analysis heart like now we have on the College of Medication. We additionally ship one among our most promising college students and residents to the College of Graz every year to coach as surgeons, purchase a basis in primary medical sciences, and upon their return to defend their dissertations at our Stomach Surgical procedure Middle in Santaras.
The academician additionally talked about that with dr. With the assistance of Aistė Kielaitė-Gulla, a connection was established with the USA: “In 2020, after the beginning of the coronavirus, Aistė proposed to determine the “Worldwide HPB Surgical procedure Journal Membership”, the thought of which is as follows: on Friday of each month, the worldwide HPB facilities come collectively, and we focus on the analysis carried out, articles, and so forth. Discussions are very fascinating, serving to to develop our circle of acquaintances and medical expertise. That is particularly helpful for younger docs and scientists,” mentioned prof. Kęstutis Strupas.
Significance of primary sciences
In response to Professor Kęstutis Strupa, this sequence of works isn’t solely science “for science’s sake”, however the type of science that reveals how questions and issues arising in medical sensible work develop into objects of scientific analysis. “Our purpose isn’t solely publication in high-ranking journals, however sensible implementation of labor,” he mentioned. Nevertheless, in keeping with the academician, being a very good working towards surgeon and a very good scientist on the identical time is a pricey skilled “symbiosis”.
“If you end up each a practitioner, a instructor, and a scientist, conducting analysis, making ready articles, and different educational actions take longer and pose extra challenges, so cooperation between “basic” scientists and practitioners is critical. At present we actually have it,” mentioned the professor. In response to him, these finding out medication and those that wish to develop into docs ought to know that if you’re solely a practitioner, i.e. with out studying something, if you’re not curious about medication as a science, your data turns into “out of date” after solely 3-4 years.
“I am unable to think about a working towards surgeon with out some contact with science. Let or not it’s only a learn. However while you write, you gather the fabric your self, expertise accumulates, you higher perceive what is going on, what you might be doing. Surgical procedure, briefly, is right incision, elimination, suturing, and proper surgical procedure requires scientific data,” he mentioned.
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2024-06-14 21:43:43