What role does prostasin play in cancer and diabetes?
When people have elevated levels of a specific protein, they are at greater risk of developing Diabetes tied together. In addition, affected persons also have an increased risk of developing die of cancer.
This was found in a new study involving Swedish experts Lund University who investigated the relationship between plasma prostasin, diabetes and the risk of cancer mortality. The study results were published in the journal “Diabetology” released.
Blood samples from more than 4,000 people evaluated
To the connection between Prostasin blood levels and cancer mortality in the general population, the team analyzed blood samples from more than 4,000 middle-aged Swedish adult participants.
The blood samples were taken more than a decade ago as part of the ongoing Malmö Diet and Cancer Study removed. Of the participants, 361 (eight percent) already had diabetes at the start of the study.
After cleaning up potential confounders, the team found that increased prostasin levels positive with the presence of Diabetes were associated. The researchers report that the probability of existing diabetes in people in the highest prostasin quartile was almost twice as high as in the lowest prostasin quartile.
702 participants developed diabetes
Next, the researchers analyzed clinical data from the same cohort (excluding 361 people with existing diabetes) up to the end of 2019. So they wanted connections with new cases of diabetes determine.
Developed over a mean follow-up of 22 years 702 participants Diabetes. Longitudinal analyzes revealed a linear relationship between prostasin and new onset diabetes.
Higher risk of diabetes with high prostasin levels
It was shown that participants with prostasin in the highest quartile 76 percent had a higher risk of developing diabetes than participants in the lowest prostasin quartile.
Interestingly, prostasin levels turned out to be lower in younger participants and people with lower blood sugar levels and better kidney function more precise predictor for diabetes, explain the researchers.
Experts believe that elevated levels of prostasin may be a compensatory response to high blood sugar (hyperglycemia), but may not be enough to halt or reverse worsening blood sugar control.
Prostasin going over the urine excretedso that one normal kidney function can contribute to maintaining an optimal prostasin blood level, the scientists explain.
Association of prostasin with cancer mortality
In further analysis, the team found that there was a significant association between prostasin and cancer mortality and the all-cause mortality are. died during the mean follow-up of 24 years 651 participants and cancer.
According to the experts, participants with prostasin blood levels in the highest quartile had an um 42 percent more likely to die from cancer than those in the lowest quartile.
For every doubling of the prostasin concentration, the risk of cancer death in participants with and without elevated blood sugar levels (impaired fasting blood sugar) is around 139 percent or. 24 percent increased. According to the researchers, however, no connection was found for cardiovascular mortality.
Risk markers for diabetes and risk of cancer death
„Prostasin is a potential new risk marker for the development of diabetes and for cancer mortality, particularly in individuals with high blood sugar levels. It is easily measurable, increasing its potential as a future warning marker“, says study author Dr. Xue Bao von der Affiliated Hospital of Nanjing University Medical School in China.
„This is the most comprehensive analysis of its kind to date and sheds new light on the biological link between diabetes and cancer‘” adds the author of the study Professor Gunnar Engström from Lund University in one press release.
How is prostasin related to tumors?
According to the experts, prostasin plays a role in the regulation of several Diabetes-associated biological signaling pathwayswhich also participated in the creation and promotion of some types of cancer involved.
Prostasin is a stimulator of epithelial sodium channels, which regulate sodium balance, blood volume and blood pressure. Of the epithelial sodium channel is associated with tumor suppression, glucose metabolism and hyperglycemia-associated tumor pathology, the researchers explain.
Prostasin might offer treatment approaches for cancer
Prostasin might mediate the process from high blood sugar to cancer, or at least act as a Markers for cancer susceptibility of people with high blood sugar, but further studies are needed to determine this.
„Prostasin may only be an indicator of disease occurrence, but it might also be causally relevant, which is exciting because it opens up the possibility of targeting this protein with future treatments for both diabetes and cancer“, so Professor Engström.
Diabetes increases risk of cancer
According to the team, previous ones delivered studies There is already evidence that diabetes is associated with an increased risk of developing various types of cancer and fatal cancers.
Another Study have shown that in people with type 2 diabetes an approx double the risk is present to develop pancreatic, endometrial and liver cancer. In addition, the risk of colon cancer was increased by 30 percent and breast cancer by 20 percent. (as)
Author and source information
This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- Xue Bao, Biao Xu, Iram Faqir Muhammad, Peter M. Nilsson, Jan Nilsson, Gunnar Engström: Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality; in: Diabetologia (veröffentlicht 04.08.2022), Diabetology
- Diabetologia: Protein that may predict future diabetes risk and death from cancer identified (veröffentlicht 04.08.2022), Diabetology
- Edward Giovannucci, David M. Harlan, Michael C. Archer, Richard M. Bergenstal, Susan M. Gapstur, et al.; : Diabetes and Cancer: A consensus report; in: Diabetes Care (veröffentlicht 01.07.2019), Diabetes Care
- Konstantinos K Tsilidis, John C Kasimis, David S Lopez, Evangelia E Ntzani, John P A Ioannidis: Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies; in: BMJ (veröffentlicht 02.02.2015), BMJ
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.
