2023-12-09 23:04:21
A new study indicates that two yeasts used in food production, Cyberlindnera jadinii et Kluyveromyces lactismay have beneficial probiotic properties for intestinal inflammation, suggesting potential new treatments for inflammatory bowel diseases.
The food industry has long used various fungal strains for their fermentation, flavor production, and ability to produce heterologous molecules. A recent study highlights the potential probiotic effects of two fungi, commonly used in food production, on intestinal inflammation. The study, published in mSystemsa journal from the American Society for Microbiology, demonstrates a possible new way to develop new probiotics.
“There is much to learn by studying the role of fungal strains in the microbiota and host health. species simply used in food processes may be the source of new probiotics,” said study lead author Mathias L. Richard, Ph.D., research director at INRAE at the Micalis Institute. from Jouy-en-Josas, France.
Understanding yeast in food and health
To date, very little is known regarding the diversity of food-borne yeasts and their potential effects on the gut microbiota and intestinal health. Yeasts are microscopic fungi made up of solitary cells that reproduce by budding. Some have been used for hundreds of years, like Saccharomyces cerevisiae for the production of wine and bread, or many others for the production of rinds or maturing of cheese, such as Debaryomyces hansenii.
The researchers conducted this new study as they work to increase knowledge regarding the potential effect of the fungal microbiota on human health. In this particular study, the idea was to specifically target mushrooms used by food companies to produce food products (cheeses, cold meats). “As our interest focuses more on the role of fungi in intestinal health and the development of inflammatory bowel diseases (Crohn’s disease and ulcerative colitis), we monitored the effect of these fungi in in vitro models. and in vivo adapted,” said Richard. .
Probiotic potential of food-borne yeasts
The researchers first selected yeasts extensively used in food production and representing a wide range of different yeast species, then tested them either in simple interaction assays with cultured human cells or in a model specific animal mimicking ulcerative colitis.
They discovered that in the collection of strains used for food production, certain strains can have a beneficial effect on the intestine and the host in an inflammatory context. They identified 2 strains of yeast, Cyberlindnera jadinii et Kluyveromyces lactis, which had potential beneficial effects on inflammatory parameters in a mouse model of ulcerative colitis. Several additional experiments were performed to try to decipher the mechanism behind these effects. In the case of C. gardensprotection appears to be driven by changes in the bacterial microbiota following administration of C. gardens to mice, which modified the sensitivity to intestinal inflammation by a still unknown mechanism.
“These 2 strains have never been specifically described with such a beneficial effect, so even if they need to be studied in more depth, and in particular to see how effective they are in humans, it is a promising discovery” , said Richard.
C. gardens et K. milk Probiotic yeast strains have the potential to combat gut inflammation, but further studies are needed to understand the mechanisms by which these strains affect gut health.
1702177766
#common #food #mushrooms #natural #probiotics
