Post-vaccination myocarditis is less severe than myocarditis caused by viral infection

Post-vaccination myocarditis is less severe than myocarditis caused by viral infection

2024-08-26 19:02:19
A patient receives a Covid-19 vaccine in Lyon on March 5, 2021.

More than three and a half years after the first dose of a Covid-19 vaccine was administered in France, what do we know about myocarditis linked to the product? A study published on Monday, August 26 Journal of the American Medical Association Research by Epi-Phare researchers sheds light on this problem. Their study shows that heart complications from myocarditis after vaccination are less severe than myocarditis-related complications that occur after Covid-19 infection.

This is the latest result to date by a team of scientists from the National Agency for the Safety of Medicines, Health Products and Health Insurance, having been presented in 2022 Increased risk of myocarditis and pericarditis In the week after receiving a Covid-19 vaccine using a messenger RNA vaccine, specifically the second dose of Moderna’s Spikevax vaccine. The discovery prompted health authorities to In November 2021, people under 30 years old were advised not to use the vaccineand therefore tend to target the Pfizer version for this group.

Myocarditis is an inflammation of the heart muscle caused primarily by viral infection and occurs primarily in young men. Although this pathology usually progresses well after treatment, some complications can be fatal. This risk after getting the shot is one of the arguments against mass vaccination campaigns during the pandemic.

‘Rare side effects’

“Myocarditis is a rare side effect of drug treatment”Mahmoud Zureik, director of Epi-Phare and coordinator of the study, expressed his approval. “Therefore, it is very important to monitor the health status of these new patients. » Therefore, his team identified all people aged 12 to 49 years who were hospitalized with myocarditis in France between December 27, 2020, when vaccination began, and June 30, 2022. After that date, people under the age of 50 Injections are rarely given. She then studied the comparative development of these cardiovascular diseases (treatments, tests performed, medications dispensed) eighteen months after the first hospitalization. This is the first international study to analyze the health of these patients over a long period of time.

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A total of 4,635 cases of myocarditis occurred during this period, 12% of which were observed within 7 days of injection of the messenger RNA vaccine (the period of highest risk), and 6% of which were observed within 30 days of injection of SARS-CoV. The average ages of men affected by these cardiovascular events were 26 and 31 years respectively. Complications considered were: cardiovascular events, readmission for myopericarditis (i.e. more or less diffuse inflammation of the myocardium and pericardium), hospitalization for more than one night and, in the worst case, death of the patient.

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