2023-08-10 07:30:00
Organoids on chips, organs in wells, or even, for the most picky, microphysiological systems. Behind these different names, a potential renewal of clinical research. This new generation of cellular models, closer to human physiology, is poised to revolutionize drug development and personalized medicine. An upheaval made possible by the rise of a disciplinary field that has been developing since the beginning of the 2000s: microfluidics. Or the control of the flow of fluids in channels finer than a hair (between 1 and 100 microns), which makes it possible to mimic the blood flows of a body or an organ. “Plumbing at the micrometric scalepopularizes Jérémy Cramer, the CEO of the start-up Cherry Biotech. This makes it possible to put human cells in a support and provide them with vascularization and an environment close to physiological reality. It is thus possible to reconstruct tissues in 3D and to imitate, in an obviously incomplete way, the functioning of an organ”.
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#Organs #chips #disrupt #clinical #trials
