Data from NIH laboratories in the United States. Omikron viruses were found to be “less” persistent in the exogenous environment than most traditional strains. Compared to previous viruses
Dr. Anant Chongkaewwatana The NSTDA virologists point out that Therefore, the reason why we are infected with this type of virus is much easier than the original strain. Probably not because viruses are more durable in the air or harder to destroy on surfaces. But it’s likely because the virus has adapted to better capture cells in our bodies and better escape immune defenses in key locations, such as the nose.
About “antiviral drugs” and their ability to “infect”
Back in November, at that time, more and more people were addicted to COVID. Paxlovid antiviral drugs…in short Pax andMolenupiravir…in short MolV more available The ability of antiviral agents to inhibit viral replication is well documented.
But… one question that has not yet been confirmed is To what extent is it possible for a patient who is on antiretroviral therapy to spread the infection to others? This is an interesting and useful question.
One study was published as a pre-print from a research team in the United States. The efficacy of Pax and MolV was compared in two experimental animals. and the bacteria can enter the lungs and result in death in laboratory animals.
The second type is Ferret… an animal that looks like a weasel. which is infected with COVID but does not have severe symptoms The infection will go to the upper respiratory tract. and can spread the infection to other ferrets
The research team brought hamsters to test the effectiveness of both antiretroviral drugs in preventing severe lung infections. It was found that mice treated with both drugs survived the infection well. while other rats were severely ill and most of them died. The results confirmed that both drugs were very effective in preventing severe symptoms in mice.
As for the results in the ferret, there is something interesting. The research team designed an experiment in which infected ferrets followed up with each antidote following infection…at doses that were equal to human body weight. Therefollowing, infected ferrets treated with antiviral drugs were combined with normal ferrets for 2 days.
After that, normal ferrets were isolated for 4 days to follow infection from nasopharyngeal samples. Compared with ferrets treated with MolV in this study, it was not or very little infectious to other ferrets.
The results of the second set of experiments were Cultivation of infected ferrets with normal ferrets treated with each type of antidote for 6 days and monitoring for viral infection in those normal ferrets. As a result, all of the ferrets treated with Pax were infected by coexistence with infected ferrets. However, the MolV-treated group was not infected.
The research team concluded that the use of MolV may result in ferrate It can prevent infection in close contact with an infected animal, but Pax may not have that feature…but this research also needs human support. which…not yet
Stories from the lab last week Dr. Anant said that a few weeks ago he received a saliva sample from a COVID patient. This case is interesting in that it is a case that has just recovered from COVID less than 3 months ago.
This makes it highly possible that this re-infection of COVID-19 comes from a virus that has changed to escape immunity well.
After successful inoculation then clones the spike gene and transmits the genetic decoding while waiting for the decryption result To what extent did the research team test the hypothesis that this virus escaped?
We incubated the virus with a monoclonal antibody, one of the antibodies that inhibits omikron viruses BA.2 and BA.5 very well.
and… incubated with serum samples of two formerly infected COVID-19 patients and had the opportunity to receivemRNA vaccine The bivalent type came regarding 1-2 months ago. And finally, incubated with a plant extract that the research team found to have the ability to inhibit the entry of the virus into cells. (One of the selected people that the research team received a research grant NRCT to find antiviral inhibitors)
The incubation of antibodies or extracts once morest the virus takes the same amount of time. By the amount used from descending, hole 1 is the highest and hole 5 is the least, while hole 6 is an empty virus. To control the amount of virus used and allow the virus to infect the cells for regarding 24 hours.
“We used dot numbers to represent the number of inactivated viruses compared to wells without inhibitors. Inhibition of the ingress of the virus at all. Immunity from the vaccine seems to be able to suppress the virus to some extent.”
The point that inhibits regarding half of the virus is The concentration in the second hole, which is 1: 200, is not very high. but still enough Interestingly, the extract was able to inhibit this type of virus well. It is no different from other strains of viruses.
This seems to suggest that the inhibitory mechanism of the extract may not depend on where the mutant spike escapes antibody binding…the research team’s current interest is how the extract binds the spike. can stop the virus
After the decryption results come out The research team found that the virus (named PSD following the infected person) The isolate is actually a descendant of the BA.2.75 virus, but it is BA.2.75 with four additional significant position changes, resulting in PSD being ranked higher than BQ.1.1. but lower than XBB
…close to strain CH.1.1 but not exactly if arranged according to mutation position This data is consistent with the above test results. Now the species in Thailand are quite diverse. Viruses in PSD format should be easy to find.
data from Argentina In a sample of more than 840,000 people, children aged 3-12 who received 2 doses of the vaccine compared with adolescents (13-17) who received 2 doses as well. There was a considerable difference in life per omikron. Two doses of the vaccine provided very low protection once morest infection in both groups, 15.9% and 26%.
If you see that it’s stuck, then it’s okay because Omicron is not violent. Let’s face it, Omikron’s efficacy in preventing deaths in children was 66.9%, compared to 97.6% among healthy adolescents. there is a risk nearby or maybe more than group 608
Because I believe that 608 of our homes receive a much higher percentage of stimulating needles than children. Dr. Anant said that Before many people pick up 6 needles, 7 needles, consider needles 1–3 for the children at home first.
