In case of mild to moderate skin reactions, appropriate treatment, such as topical corticosteroids and antihistamines, may be considered.
If Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is suspected, or if bullous lesions appear, treatment should be discontinued immediately and the patient should be referred to a specialist. Histological confirmation, which may require the performance of several biopsies, is essential to allow diagnosis and early management of severe skin reactions.
In case of worsening grade 2, grade 2 with fever or grade 3 skin reactions, treatment should be withheld until the reaction resolves to ≤ grade 1 and specialist consultation should be considered. The treatment can be resumed at the same dose or at a reduced dose (reduction of one dose level) (see section 4.2 of the SmPC).