2023-06-09 13:54:00
13:54 GMT, 9 June 2023
A new study, involving dozens of aging researchers around the world, shows that a deficiency of taurine – a nutrient produced by the body and found in many foods – plays a directive role in aging in animals.
Sputnik
The same study also found that taurine supplementation can slow the aging process in worms, mice and monkeys and can extend the healthy lifespan of middle-aged mice by up to 12%.
“For the past 25 years, scientists have been trying to find factors that not only allow us to live longer, but also increase healthy lifespan, which is the time in which we remain healthy in our old age.”
Over the past two decades, efforts to identify interventions that improve health in old age have intensified as people live longer, and scientists are finding that the aging process can be manipulated. Many studies have found that various molecules that travel through the bloodstream are associated with aging, but scientists are not sure whether or not these molecules actively direct the aging process. If a molecule is a driver of aging, restoring its youthful levels would delay aging and increase years spent in good health.
Professor Yadav became interested in taurine, for the first time, during his previous research into osteoporosis and revealed the role of taurine in building bone. Around the same time, other researchers found that taurine levels are linked to immune function, obesity, and nervous system function.
“We realized that if taurine regulates all these processes that decline with age, then perhaps the levels of taurine in the bloodstream might affect overall health and lifespan,” Yadav added.
According to the study published in the Scientific Journal: “Taurine decreases with age, and supplementation increases lifespan in mice.”
Yadav’s team looked at levels of taurine in the bloodstreams of mice, monkeys, and humans, and found that the abundance of taurine declines dramatically with age in humans. The levels of taurine in 60-year-olds were regarding a third of those in children at just five years of age. “From there, we set out to ask if taurine deficiency is a driver of the aging process, and we did a large experiment in mice,” says Yadav.
The researchers started with approximately 250 14-month-old female and male mice (regarding 45 years old compared to humans), and each day, they gave half of the mice a dose of taurine or a control solution.
At the end of the experiment, Yadav and his team found that taurine increased life expectancy by 12 percent in female rats and 10 percent in male rats. For mice, this meant an additional three to four months, the equivalent of regarding seven or eight years in humans. To find out how taurine affects health, Yadav brought in other senior researchers who have been investigating the effect of taurine supplementation on health and lifespan in several species.
Experts measured various different health parameters in mice, and found that at age two (60 in humans), animals given taurine supplements for one year were healthier in nearly every respect than their untreated counterparts. Researchers found that taurine prevents age-related weight gain in female mice, increases energy expenditure, increases bone mass, improves muscle endurance and strength, reduces depressive and anxiety-like behaviors, reduces insulin resistance, and boosts the immune system, among other benefits.
“Not only did we find that the animals live longer, we also found that they lead healthier lives,” says Yadav. Similar health effects of taurine supplementation were observed in middle-aged rhesus monkeys, which were given daily taurine supplements for six months. Taurine prevented weight gain, reduced blood glucose and markers of liver damage, increased bone density in the spine and legs, and improved the health of their immune systems.
Taurine has also been shown to improve many functions that decline with age, reduce the number of old cells that have to die and release harmful substances, and increase the number of stem cells in some tissues that help heal following injury.
Researchers don’t yet know if taurine supplements will improve health or increase longevity in humans, but two trials conducted suggest that taurine has potential.
First, Yadav and his team looked at the relationship between taurine levels and regarding 50 health parameters in 12,000 European adults aged 60 and over. In general, people with higher levels of taurine were healthier, with fewer cases of type 2 diabetes, lower levels of obesity, lower high blood pressure, and lower levels of inflammation.
“These are associations that do not prove causation, but the findings are consistent with the possibility that taurine deficiency may contribute to human ageing,” Yadav said.
The second study tested whether taurine levels would respond to exercise that is known to improve health. Researchers measured taurine levels before and following a variety of male athletes finished a strenuous cycling workout. They found a significant increase in taurine among all groups of athletes (sprinters, endurance runners, and bodybuilders). normal) and sedentary individuals.
“Regardless of the person, everyone had increased levels of taurine following exercise, which indicates that some of the health benefits of exercise may come from the increase in taurine,” Yadav said. “Despite all these indications, the clinical trial in humans remains the only means that will determine Whether taurine really has health benefits”.
He pointed out that “taurine has some advantages, as it is produced naturally in our bodies, and it can be obtained naturally from the diet, and it has no known toxic effects, and it can be enhanced through exercise.”
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