[의학신문·일간보사=이상만 기자] One of the rare incurable diseases ‘still’s disease’A study on the pathogenesis of.
Still’s disease, one of the rare and intractable autoimmune diseases, is 16before three ‘still’s disease(systemic juvenile idiopathic arthritis)’by, After that, the patient ‘adult still’s disease’is called.
population 10per ten thousand 0.16-0.4Fever and skin rash of unknown cause, joint and muscle pain, Sore throat, hepatomegaly, splenomegaly, Inflammation in various parts of the body, including increased lymph nodes, sharply reduces the quality of life.. The pathogenesis has not yet been elucidated., infection, immune disorders, Genetic factors are suspected.
infected with it, malignant tumor, It is difficult to clearly distinguish it from other autoimmune diseases with fever., There is no separate diagnostic method, so it is difficult to diagnose.. However, iron in the blood(Fe)ferritin, an indicator of the storage state of(ferritin) There is a characteristic that the level is significantly higher than normal.
Among these, Hyuna Kim, Department of Rheumatology, Ajou University Hospital·Professor Jiwon Kim’s team reviewed the pathogenesis of Still’s disease through a review of various previously published papers. ‘neutrophils’Wow ‘NET’confirm that it is related to, It is noted for its potential as a biomarker for diagnosis..
white blood cells in the body 40-70%Neutrophils occupying the body play an important role in eliminating pathogens invading our body.NET It also has the ability to remove pathogens that have invaded from the outside., Autoimmune diseases in people with high autoimmune or autoinflammation susceptibility, May cause auto-inflammatory diseases.
The research team found that viral hepatitis, Neutrophils and neutrophils in inflammatory processes caused by bacterial hepatitis or environmental triggers NETHe explained that it seems to develop Still’s disease, an auto-inflammatory disease in which immune cells that protect our body from bacteria or viruses attack our body in reverse and cause inflammation due to excessive activation of.
Professor Hyuna Kim “The pathogenesis of Still’s disease is still unclear.”saying “However, in this study, neutrophils and NETWhile confirming that it is related to the pathogenesis of, It is hoped that it will help in the discovery of biomarkers for the development of new treatments and prediction of prognosis in the future.”said.
On the other hand, this study 2021year 12month of world authority SCI academic journal International Journal of Molecular Sciences(International Journal of Molecular Science)to ‘An Update on the Pathogenic Role of Neutrophils in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still’s Disease(Update on the pathogenic role of neutrophils in systemic juvenile idiopathic arthritis and adult-type Still’s disease.)published under the title.