Thairath Online
19 Feb 2022 16:20
Dr. Anan reveals research from the Netherlands.Antibody 87G7 New Hope Stops All Virus Species
On February 19, 2022, Dr.Anan Chongkaewwattana Virologist Biotech NSTDA has posted a message via Facebook. Anan Jongkaewwattana that due to mutations on the spike protein of the virusOmikronBoth BA.1 and BA.2 antibodies isolated from previously infected patients are highly likely to be unable to capture and suppress these viruses.
Recent studies have shown that BA.2 is likely to be resistant to almost all developing therapeutic antibodies. The cause is a mutation that is scattered on the protein thorn that it is difficult to find antibodies to escape that mutation and catch it…but our bodies make a very wide variety of antibodies. and study results from natural infections or from vaccination This leads us to believe that there must still be those antibodies that capture the omikron mix. in our body Only finding and isolating those antibodies from pools containing other antibodies. It’s very difficult to do. And it really depends on luck.
The good news today is that the efforts of researchers in a race to find antibodies that can capture and stop all strains of the coronavirus appear to be realistic. by the latest research by a research team from the Netherlands The researchers (a long-standing and very strong group of coronavirus researchers) found that one cloned antibody, called 87G7, was able to pass through the omikron barriers BA.1 and BA.2 to bind to spiny proteins. and inhibit the entry of the virus into cells. The results of trials using this antibody in laboratory animals exposed to the virus showed that it was very effective at preventing infection.
The research team conducted an in-depth study that found that the antibody 87G7 binds to the spike protein at a key intracellular strategy (called RBD) at the six amino acid sites (green in the image), the unchanged site. in all virus strains now which the omikron group found to change will be the red part. will not match where the 87G7 went into the grip, which may be that This green amino acid location is difficult to change. Because if they change, the function of the spike protein is ineffective or bad, the virus needs to keep this location unchanged.
If so, 87G7 would be an antibody that would be capable of suppressing all virus strains if the virus had not mutated added to these six amino acids. The research being conducted here is remarkable, and I believe that 87G7 is not. The only clone we will find. There will be more to follow.
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