“Medicine yourself for others to eat” from the case of the online world has shared the story of move 70 years old withsymptomIt’s tight, but it doesn’t look like anything is pressed once morest it. Where there is no anguish breath feeling tired following choking on food When taking a history, it was found thatsublingual lozenges which ismedicineheart, although it is not a congenital disease of one’s owndrugThis one is for Grandma to eat. because they have similar symptoms Many people may have heard the advice that should not be taken.self-medication for others to eat Even if it’s the same disease, why?take medicineIt’s the same that everyone else eats. but it doesn’t work like the others, or risk deathYes, what is the reason for these differences?
Pharmacist gave knowledge Why should we not takeself-medication for others to eat These factors can be distinguished as follows:
Different drug response factors
physical factors such as gender, age, gastrointestinal pH bowel movements Liver, kidney function, user’s geneticsdrug Other illnesses, concomitant medications
sex It’s part of the factors that cause different responses to medications. The role of sex hormones is heavily involved, including the structure of the body. Females have more fat accumulation, so fat-soluble drugs stay in the body longer than males.
age It is a factor that is directly related to the change in drug action. because of the older age It is associated with reduced gastrointestinal acidity. (that is, the digestive tract is more alkaline) making the drug acidic poorly absorbed But the alkaline drug is better absorbed. or drugs that rely on acid to dissolve (eg calcium carbonate) will be absorbed less. Digestive movements too.
when getting older The digestive tract will move down. drugIt will be transported to the intestines slowly. The absorption of the drug into the body will also slow down. Besides that The functioning of the liver and kidneys is naturally reduced. It will make drugs that rely on the liver and kidneys to eliminate them. Remaining in the body for a longer time Therefore, the dosage must be adjusted to suit the function of the liver and kidneys.
There were also other ailments. congenital diseasesome result in adverse reactions when givendrugsome kind enter While others are not, such as asthma, emphysema, may cause people to receive group drugs. beta blockers have symptoms of exacerbation while others are not or people with G-6-PD deficiency, when taking certain medications, such as sulfonamides, can lead to dangerously acute hemolysis.
concomitant medications : Each person has a different underlying disease. take medicineOther profiles are not the same and this can affect drug response. It can cause drug interactions that are not the same.
heredity : is the main reason for the difference in response todrugIn each individual, different genetics will result in sensitivity. (susceptibility) to the drug is not the same. Heredity affects the enzyme used to change drugs. causing some people to take a certain dose of the drug is effective. while others took the same dose of the same drug and became poisoned.
Genetics also affect the risk of drug allergy, for example, some individuals have the HLA-B*5801 gene that increases the likelihood of allergy to allopurinol. or some individuals have the HLA-B*1502 gene that increases the likelihood of an allergic reaction to carbamazepine. In the past, there was not much knowledge of genetics. We can’t know that Why some people take this drug and have allergic reactions, some are not. But with more genetic knowledge, we found that some “markers” in the genetic material affect drug sensitivity. or response to medication leading to a new science called “Pharmacogenomics” helps us understand the role of genetic variation in drug response and drug allergy. This makes it possible to predict the likelihood of drug allergy in a person and find ways to avoid high-risk drug allergy.
Environmental factors/lifestyle/food
such as food intake, alcohol consumption, smoking, stress, sleep exercise, occupation
alcohol and cigarettes : It is a clear external factor. affectmedicineFood intake, alcohol and cigarettes alter the activity of enzymes used to break down drugs. causing many drugs that have different effects from the original or alcohol “added” to the effects ofdrugthat until it becomes dangerous, for example, taking drugs that have a central nervous system depressant effect together with alcohol can have a severe depressant effect.
food to eat : Some fruits that affect the activity of drug-breaking enzymes, such as grapefruit, can interact with many drugs. or occupations that obtain certain substances that alter the performance of enzymes used to destroy drugs
so self-medication for others to eat Therefore, it is inappropriate. although the symptoms may be similar But it may be caused by different diseases and causes. or if sick with the same disease But the dosage and concentration of the drug may not be the same. because the negative consequences may follow more than expected
Thank you information from Pharmacist Pharmchompoo
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