“Early diagnosis of senile dementia… Contributing to the improvement of public health and welfare in an aging society”
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(Daejeon = Yonhap News) Reporter Junho Kim = The Korea Research Institute of Bioscience and Biotechnology announced on the 11th that a research team led by Dr. Lim Eun-kyung of the Bio-Nano Research Center and a joint research team of Professor Moon Min-ho of Konyang University developed a system that can diagnose early Alzheimer’s disease through blood tests.
Alzheimer’s disease, a senile dementia accompanied by memory loss and cognitive impairment, has no effective treatment so far, so it is best to slow the progression of symptoms through accurate early diagnosis.
The research team confirmed the fact that miR-574, a type of microRNA (miRNA), was greatly increased in the blood of Alzheimer’s disease patients, and developed a diagnostic system that can detect it.
miRNA is a type of RNA (ribonucleic acid) that controls gene expression in living things. It is very small in size and uses a carrier such as exosomes (a nanometer-sized organelle secreted to exchange information between cells) through the blood-brain barrier. (BBB) can pass. The research team explained that by analyzing this process, it is possible to indirectly determine the degree of brain disease progression.
The diagnostic system of the hydrogel structure developed by the research team enables high-sensitivity detection of genes without additional additives or separate processes.
When the biomarker (biomarker) is detected, a fluorescence phenomenon appears, and it is designed to diagnose Alzheimer’s disease.
Dr. Lim Eun-kyung said, “It is excellent to be able to detect the biomarker of Alzheimer’s disease with high sensitivity using only blood. .
The results of this study were published online on the 12th of last month in ‘Biosensors and Bioelectronics’, an international journal in the field of biosensors.
kjunho@yna.co.kr
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